GRM4, glutamate metabotropic receptor 4, 2914

N. diseases: 54; N. variants: 5
Disease: Motor symptoms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0426980
Disease: Motor symptoms
Motor symptoms 		0.020 Biomarker phenotype BEFREE This work provides a demonstration that a positive allosteric modulator of metabotropic glutamate receptor 4 can alleviate the motor symptoms of PD and the motor complications induced by l-dopa in primates. 30216534 2018
CUI: C0426980
Disease: Motor symptoms
Motor symptoms 		0.020 AlteredExpression phenotype BEFREE This work led to the identification of compound 40, a potent and selective mGluR4 positive allosteric modulator (PAM) with good water solubility and demonstrating consistent activity across validated preclinical rodent models of PD motor symptoms after intraperitoneal administration: haloperidol-induced catalepsy in mouse and the rat 6-hydroxydopamine (6-OHDA) lesion model. 28902994 2017