GRM5, glutamate metabotropic receptor 5, 2915

N. diseases: 189; N. variants: 37
Disease: Status Epilepticus ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.310 Biomarker disease BEFREE Interestingly, in both male and female mice, mGluR5 function persists in the astrocyte throughout the process of epileptogenesis following status epilepticus. 30504280 2019
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.310 Biomarker disease CTD_human It is possible that mGluR5 may play a negative role in initiation of status epilepticus by interacting with muscarinic acetylcholine receptor in mGluR5+/+ mice. 18774262 2008
CUI: C0038220
Disease: Status Epilepticus
Status Epilepticus 		0.310 Biomarker disease CTD_human Thus, we conclude that the reduction of mGluR LTD after pilocarpine-induced status epilepticus is the result of the subtype-specific downregulation of mGluR5 and associated downstream signaling components. 17634364 2007