Major Depressive Disorder
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis of depression identifies 102 independent variants and highlights the importance of the prefrontal brain regions.
|
30718901 |
2019 |
Major Depressive Disorder
|
0.490 |
GeneticVariation
|
disease |
BEFREE |
In vivo metabotropic glutamate receptor 5 availability-associated functional connectivity alterations in drug-naïve young adults with major depression.
|
30553696 |
2019 |
Major Depressive Disorder
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways.
|
29662059 |
2018 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
BEFREE |
Unlike the rapidly acting glutamatergic agent ketamine, mGluR5-specific modulation has not yet shown antidepressant efficacy in MDD and bipolar disorder.
|
29100629 |
2018 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
BEFREE |
We provide an overview of the justification of targeting mGlu5 receptors in the treatment of these disorders, summarize the preclinical evidence for negatively modulating mGlu5 receptors as a therapeutic target for major depressive disorders and nicotine dependence, and highlight the outcomes of recent clinical trials.
|
29628194 |
2018 |
Major Depressive Disorder
|
0.490 |
GeneticVariation
|
disease |
GWASCAT |
Meta-analysis of genome-wide association studies for neuroticism in 449,484 individuals identifies novel genetic loci and pathways.
|
29942085 |
2018 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
BEFREE |
We observed a significant ketamine-induced reduction in mGluR5 availability (that is, [<sup>11</sup>C]ABP688 binding) in both MDD and control subjects (average of 14±9% and 19±22%, respectively; P<0.01 for both), which persisted 24 h later.
|
28397841 |
2018 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
BEFREE |
Basimglurant, a novel mGlu5-negative allosteric modulator under development for the treatment of major depressive disorder, is cleared via cytochrome P450 (P450)-mediated oxidative metabolism.
|
27821711 |
2017 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
BEFREE |
Moving from in vitro data and preclinical studies, we discuss the potential impact of drugs targeting mGlu2, mGlu3, mGlu4 and mGlu5 receptor ligands on active neurodegeneration associated with AD, PD, schizophrenia, and MDD.
|
27140693 |
2017 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
BEFREE |
1.The emerging technique of employing intravenous microdose administration of an isotope tracer concomitantly with an [<sup>14</sup>C]-labeled oral dose was used to characterize the disposition and absolute bioavailability of a novel metabotropic glutamate 5 (mGlu5) receptor antagonist under clinical development for major depressive disorder (MDD).2.
|
27123695 |
2017 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
PSYGENET |
A comprehensive understanding of mGluR5 regulation in major depression, particularly in comparison to schizophrenia, is crucial as this has extensive implications for mGluR5 targeting novel therapeutics, especially considering that opposing modulation of mGluR5 is of therapeutic interest for these two disorders.
|
24472577 |
2014 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
BEFREE |
A comprehensive understanding of mGluR5 regulation in major depression, particularly in comparison to schizophrenia, is crucial as this has extensive implications for mGluR5 targeting novel therapeutics, especially considering that opposing modulation of mGluR5 is of therapeutic interest for these two disorders.
|
24472577 |
2014 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
PSYGENET |
Our postmortem studies indicate robust deficits in prominent postsynaptic proteins including N-methyl-d-aspartate (NMDA) receptor subunits (NR2A, NR2B), metabotropic glutamate receptor subtype 5 (mGluR5) and postsynaptic density protein 95kDa (PSD-95) in the PFC in major depressive disorder (MDD).
|
21635931 |
2011 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
BEFREE |
Our postmortem studies indicate robust deficits in prominent postsynaptic proteins including N-methyl-d-aspartate (NMDA) receptor subunits (NR2A, NR2B), metabotropic glutamate receptor subtype 5 (mGluR5) and postsynaptic density protein 95kDa (PSD-95) in the PFC in major depressive disorder (MDD).
|
21635931 |
2011 |
Major Depressive Disorder
|
0.490 |
Biomarker
|
disease |
PSYGENET |
Our findings provide the first evidence that chronic CORT exposure regulates the expression of mGluR5 and are in line with previous postmortem and imaging studies showing reduced mGluR5 in MDD.
|
20600666 |
2010 |