GRM5, glutamate metabotropic receptor 5, 2915

N. diseases: 189; N. variants: 37
Disease: Neuropathy, Painful ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1850383
Disease: Neuropathy, Painful
Neuropathy, Painful 		0.010 AlteredExpression disease BEFREE Our findings suggest that paclitaxel-induced painful neuropathy is associated with increased presynaptic mGluR5 activity at the spinal cord level, which serves as upstream signaling for PKC-mediated tonic activation of NMDARs. mGluR5 is therefore a promising target for reducing chemotherapy-induced neuropathic pain. 29074619 2017