|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The treatment by gavage with a mixture of fish and soybean oils (1:1 ratio) both reduced the melanoma growth and the levels of leukotriene B<sub>4</sub> (LTB<sub>4</sub>), prostaglandin E<sub>2</sub> (PGE<sub>2</sub>), PGE<sub>2</sub>/prostaglandin E<sub>3</sub> (PGE<sub>3</sub>) ratio, and CXC ligand 1 (CXCL1) and increased the levels of interleukin 10 (IL-10) to IL-10/CXCL1 ratio in the melanoma microenvironment.
|
31374840 |
2019 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By PCR and Luminex analyses we found that a majority of malignant melanoma (MM) cell lines expressed chemokines CXCL1/Gro<i>α</i>, CXCL8/IL-8, CXCL12/SDF-1 and CCL2.
|
30221044 |
2018 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Among them, CXCL1 (melanoma growth-stimulating activity α) and IL8 (interleukin 8) have been shown to stimulate melanoma growth in vitro and in vivo.
|
22225770 |
2012 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results show that anti-melanoma effects of thiazolidinediones involve an inhibition of the MITF/CXCL1 axis and highlight the key role of this specific pathway in melanoma malignancy.
|
20596077 |
2011 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We found that the expression of HLA-DR in these tumors rather coincides with the expression of CXCL-1 and CXCL-8 chemokines, both known to be expressed in tumors that invade early and are related to invasive stages of melanoma.
|
19574933 |
2009 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We show that CXCL1 a chemokine that is down regulated in breast cancer cells by Curcumin in an NFkappaB dependent manner is expressed at variable levels in human melanomas.
|
20030852 |
2009 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Another protein, m/z 7,866, was identified as CXC chemokine ligand 1 (CXCL1) or GRO-alpha, a chemokine associated with melanoma formation and some epithelial cancers.
|
16452192 |
2006 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
LHGDN |
As determined by ELISA, endothelin-1 (ET-1) induces CXCL1 and CXCL8 secretion in three human melanoma cell lines in a concentration-dependent fashion.
|
16098041 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In addition, the melanoma growth and migration stimulatory chemokines CXCL1 and CXCL2 were significantly up-regulated in the cocultured fibroblasts.
|
15899804 |
2005 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Growth-regulated oncogene-1 (GRO-1) is an autocrine growth factor in melanoma and is a member of the CXC family of chemokines which promote chemotaxis of granulocytes and endothelia through binding to CXC receptor 2.
|
15218300 |
2004 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, CXCL1 antibody blocks IKK activity and inhibits the proliferation of melanoma cells to further support the concept that the constitutive activation of NF-kappaB and autocrine effects of CXCL1 play an important role in the pathogenesis of melanoma.
|
11406569 |
2001 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The MGSA/GRO protein is endogenously expressed in almost 70% of the melanoma cell lines and tumors, but not in normal melanocytes.
|
11030154 |
2000 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of the CXC chemokine MGSA is often deregulated during viral infection, chronic inflammation, and melanoma tumor progression.
|
9230219 |
1997 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma growth stimulatory activity (MGSA)/growth regulated (GRO) and interleukin-8 (IL-8) are highly related chemokines that have a causal role in melanoma progression.
|
8530498 |
1995 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We have previously shown that the NF-kappa B element at -83 to -65 is essential for basal and cytokine induced MGSA/GRO alpha promoter activity in the Hs294T melanoma and normal retinal pigment epithelial (RPE) cells, respectively.
|
7479086 |
1995 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We have characterized constitutive and cytokine-regulated MGSA/GRO alpha, -beta, and -gamma gene expression in normal retinal pigment epithelial (RPE) cells and a malignant melanoma cell line (Hs294T) to discern the mechanism for MGSA/GRO constitutive expression in melanoma.
|
8264646 |
1994 |
|
melanoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Melanoma cell lines were positive for MGSA protein in both the presence and the absence of serum.
|
2095366 |
1990 |
|
melanoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The level of MGSA mRNA in melanoma cells is strongly elevated by treatment with MGSA.
|
2970963 |
1988 |