GRP, gastrin releasing peptide, 2922

N. diseases: 172; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0018671
Disease: Head and Neck Neoplasms
Head and Neck Neoplasms 		0.300 Biomarker group CTD_human SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 2004
CUI: C0018675
Disease: Head Neoplasms
Head Neoplasms 		0.300 Biomarker group CTD_human SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 2004
CUI: C0027533
Disease: Neck Neoplasms
Neck Neoplasms 		0.300 Biomarker group CTD_human SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 2004
CUI: C0278996
Disease: Malignant Head and Neck Neoplasm
Malignant Head and Neck Neoplasm 		0.300 Biomarker disease CTD_human SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 2004
CUI: C0746787
Disease: Cancer of Neck
Cancer of Neck 		0.300 Biomarker disease CTD_human SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 2004
CUI: C0751177
Disease: Cancer of Head
Cancer of Head 		0.300 Biomarker disease CTD_human SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 2004
CUI: C0887900
Disease: Upper Aerodigestive Tract Neoplasms
Upper Aerodigestive Tract Neoplasms 		0.300 Biomarker group CTD_human SRC family kinases mediate epidermal growth factor receptor ligand cleavage, proliferation, and invasion of head and neck cancer cells. 15342401 2004
CUI: C0002622
Disease: Amnesia
Amnesia 		0.300 Therapeutic disease CTD_human We examined memory improvement with respect to the effects of gastrin-releasing peptide (GRP) in male C57BL/6J mice under conditions of experimentally induced amnesia. 11564462 2001
CUI: C0233750
Disease: Hysterical amnesia
Hysterical amnesia 		0.300 Therapeutic phenotype CTD_human Posttraining administration of gastrin-releasing peptide improves memory loss in scopolamine- and hypoxia-induced amnesic mice. 11564462 2001
CUI: C0233796
Disease: Temporary Amnesia
Temporary Amnesia 		0.300 Therapeutic phenotype CTD_human Posttraining administration of gastrin-releasing peptide improves memory loss in scopolamine- and hypoxia-induced amnesic mice. 11564462 2001
CUI: C0236795
Disease: Dissociative Amnesia
Dissociative Amnesia 		0.300 Therapeutic phenotype CTD_human Posttraining administration of gastrin-releasing peptide improves memory loss in scopolamine- and hypoxia-induced amnesic mice. 11564462 2001
CUI: C0262497
Disease: Global Amnesia
Global Amnesia 		0.300 Therapeutic phenotype CTD_human Posttraining administration of gastrin-releasing peptide improves memory loss in scopolamine- and hypoxia-induced amnesic mice. 11564462 2001
CUI: C0750906
Disease: Tactile Amnesia
Tactile Amnesia 		0.300 Therapeutic phenotype CTD_human Posttraining administration of gastrin-releasing peptide improves memory loss in scopolamine- and hypoxia-induced amnesic mice. 11564462 2001
CUI: C0750907
Disease: Amnestic State
Amnestic State 		0.300 Therapeutic phenotype CTD_human Posttraining administration of gastrin-releasing peptide improves memory loss in scopolamine- and hypoxia-induced amnesic mice. 11564462 2001
CUI: C0019207
Disease: Hepatoma, Morris
Hepatoma, Morris 		0.300 Biomarker disease CTD_human Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours. 2910524 1989
CUI: C0019208
Disease: Hepatoma, Novikoff
Hepatoma, Novikoff 		0.300 Biomarker disease CTD_human Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours. 2910524 1989
CUI: C0023904
Disease: Liver Neoplasms, Experimental
Liver Neoplasms, Experimental 		0.300 Biomarker phenotype CTD_human Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours. 2910524 1989
CUI: C0086404
Disease: Experimental Hepatoma
Experimental Hepatoma 		0.300 Biomarker disease CTD_human Neuroendocrine dysdifferentiation and bombesin production in carcinogen-induced hepatocellular rat tumours. 2910524 1989
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.100 Biomarker disease BEFREE <sup>68</sup>Ga-RM2 is a bombesin (BBN) analog that targets the gastrin releasing peptide receptors (GRPR) overexpressed in many cancer cells, including prostate cancer (PC). 31478089 2020
CUI: C0600139
Disease: Prostate carcinoma
Prostate carcinoma 		0.100 Biomarker disease BEFREE <sup>68</sup>Ga-RM2 is a bombesin (BBN) analog that targets the gastrin releasing peptide receptors (GRPR) overexpressed in many cancer cells, including prostate cancer (PC). 31478089 2020
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 Biomarker group BEFREE This review will focus on how GPCRs for VIP and BB are molecular targets for early detection and treatment of cancer. 31074514 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.100 AlteredExpression group BEFREE This review discusses the overexpression of Bn receptors in different cancers and various approaches to target these receptors for therapeutic and diagnostic interventions in human malignancies. 31295552 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Blockade with [d-Phe<sup>6</sup>,Leu-NHEt<sup>13</sup>,des-Met<sup>14</sup>]bombesin(6-14) significantly reduced the average uptake of [<sup>68</sup>Ga]Ga-ProBOMB1 in tumors by 62%. 30775647 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE Bombesin (Bn) receptors have shown great promise for tumor targeting due to their increased expression in a variety of human cancers, including prostate, breast, small cell lung, and pancreatic cells. 31295552 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.100 Biomarker group BEFREE In nude mice, MDA-MB-231 tumor uptake profiles were slightly different; the BN peptide with Ahx spacer and linked to DOTA through cyclen exhibited higher tumor uptake (2.32% ID/g at 1 h post-injection) than other radiolabeled BN peptides investigated in this study. 31502101 2019