Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Paclitaxel-loaded nanobubble targeted to pro-gastrin-releasing peptide inhibits the growth of small cell lung cancer.
|
31406477 |
2019 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Additionally in stage III and IV, the concordance rates of ProGRP ≥71 ng/L and ProGRP ≥99 ng/L were also higher than ProGRP ≥300 ng/L (both P<0.001), which was conventionally indicated for SCLC.
|
31179060 |
2019 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Bombesin (BB)-like peptides synthesized by neuroendocrine tumor small cell lung cancer (SCLC) bind to BB receptors (BBRs), causing phosphatidylinositol turnover and phosphorylation of extracellular signal-regulated kinase (ERK).
|
31074514 |
2019 |
Small cell carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a number of tumors, such as small cell lung cancer (SCLC), bombesin (BB) like peptides and neurotensin (NTS) function as autocrine growth factors whereby they are secreted from tumor cells, bind to cell surface receptors and stimulate growth.
|
30008698 |
2018 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results suggested a significant correlation between Pro-GRP and the T lymphocyte subpopulation in SCLC patients.
|
29399130 |
2018 |
Small cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum ProGRP and NSE levels predicting small cell lung cancer transformation in a patient with <i>ALK</i> rearrangement-positive non-small cell lung cancer: A case report.
|
30214557 |
2018 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study has found that there is a potential role for ProGRP and NSE in both therapy monitoring and predicting survival in SCLC patients.
|
26886220 |
2016 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
GRP, NT and AM bind to G-protein coupled receptors causing phosphatidylinositol turnover or elevated cAMP in SCLC cells.
|
16633328 |
2006 |
Small cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We investigated the effects of the glucocorticoid, dexamethasone (Dex), on expression of the gastrin-releasing peptide (GRP) receptor by human small cell lung carcinoma (SCLC) SHP77 cells.
|
14698533 |
2004 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
LHGDN |
Pro-gastrin-releasing peptide (ProGRP), neuron specific enolase (NSE), carcinoembryonic antigen (CEA) and cytokeratin 19-fragments (CYFRA 21-1) in patients with lung cancer in comparison to other lung diseases.
|
12820318 |
2003 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Amplification of the preproGRP message was detected in SCLC cell lines (LU165, SBC1, SBC2, and SBC3) but not in other NSCLC cell lines (A549, ABC1, EBC1, and Oka-1).
|
12733150 |
2003 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
LHGDN |
Gastrin-releasing peptide (Pro-GRP), a member of the bombesin family of peptides, has been shown to have mitogenic activity in small cell lung carcinoma (SCLC), and to be produced by SCLC in an autocrine fashion.
|
12820319 |
2003 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the effects of growth hormone-releasing hormone (GHRH) antagonists, JV-1-65 and JV-1-63, and bombesin/gastrin-releasing peptide (BN/GRP) antagonist RC-3940-II on DMS-153 human small cell lung carcinoma xenografted into nude mice.
|
14660794 |
2003 |
Small cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
LHGDN |
Finally, production of proGRP protein in SCLC tumor was evaluated by using immunohistochemical staining with a polyclonal human anti-proGRP antibody.
|
12474049 |
2002 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Finally, production of proGRP protein in SCLC tumor was evaluated by using immunohistochemical staining with a polyclonal human anti-proGRP antibody.
|
12474049 |
2002 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We conclude that mRNA for the neuropeptides gastrin-releasing peptide and arginine vasopressin and the cholecystokinin receptor B were most SCLC-specific and RT-PCR for these markers could be used to distinguish between SCLC and NSCLC.
|
11429190 |
2001 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
In nude mice, a subcutaneously-inoculated tumor of SBC5 cells infected with AdGRP-TK in advance regressed completely after intraperitoneal administration of GCV.
|
11299758 |
2001 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Autocrine growth factors such as neuroendocrine regulatory peptides (eg, bombesin/gastrin-releasing peptide) are prominent in SCLC.
|
11479891 |
2001 |
Small cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A hallmark of small cell lung carcinoma (SCLC) is the expression of autocrine growth factors such as neurotensin and gastrin-releasing peptide, which bind to cellular receptors and stimulate cell division.
|
10915224 |
2000 |
Small cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
In this study, we determined whether mRNA of bombesin receptors is detectable in PB or peripheral blood progenitor cell (PBPC) samples from patients with small cell lung cancer.
|
10810412 |
2000 |
Small cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
RT-PCR analysis demonstrated expression of GRP mRNA in the SBC5 human SCLC cell line but not in the RERF human SCLC cell line, the A549 human lung adenocarcinoma cell line or the HeLa human uterine cervix epithelioid carcinoma cell line.
|
10699954 |
2000 |
Small cell carcinoma of lung
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gastrin-releasing peptide (GRP), a member of the bombesin family of peptides, has been shown to have mitogenic activity in small cell lung carcinoma (SCLC), and to be produced by SCLC in an autocrine fashion.
|
10545285 |
1999 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
GRP is a known autocrine growth factor in small cell lung cancer and other neuroendocrine tumors.
|
9622091 |
1998 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
Induction of gastrin releasing peptide by all-trans retinoic acid in small cell lung cancer cells.
|
9468588 |
1998 |
Small cell carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
A number of small cell lung cancer cell (SCLC) lines were tested, and the IC50 for DAB389 GRP ranged from 1.1 to 85 nM.
|
9000570 |
1997 |