GSK3B, glycogen synthase kinase 3 beta, 2932

N. diseases: 393; N. variants: 25
Disease: Unipolar Depression ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.360 GeneticVariation disease BEFREE A haplotype of glycogen synthase kinase 3β is associated with early onset of unipolar major depression. 20618448 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.360 Biomarker disease CTD_human A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. 20534517 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.360 GeneticVariation disease BEFREE Brain Volume-Related Polymorphisms of the Glycogen Synthase Kinase-3β Gene and Their Effect on Antidepressant Treatment in Major Depressive Disorder. 31189175 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.360 Biomarker disease CTD_human Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. 20357757 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.360 Biomarker disease BEFREE Genetic association of the interaction between the BDNF and GSK3B genes and major depressive disorder in a Chinese population. 20033742 2010
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.360 GeneticVariation disease BEFREE Notably, another promotor SNP (rs334558) of the GSK-3β gene is reportedly associated with unipolar depression, bipolar disorders, and dementia. 31742842 2019
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.360 Biomarker disease BEFREE Our results provide evidence that the GSK3B gene could be a promising region which contains genetic risk for both major depressive disorder and schizophrenia in the Han Chinese population. 26186530 2015
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression 		0.360 GeneticVariation disease BEFREE The combined effects of the BDNF and GSK3B genes modulate the relationship between negative life events and major depressive disorder. 20682308 2010