Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We recently demonstrated that heat shock protein 90 (HSP90) is involved in the regulation of runt-related transcription factor 2 via the AKT/GSK-3β/β-catenin signaling pathway in OS.
|
31595984 |
2020 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The expression of Wnt3α and p-GSK-3β were also significantly upregulated indicating that the Wnt/β-catenin signaling pathway was activated during the EMT of osteosarcoma driven by BMP-2.
|
30737824 |
2019 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glycogen synthase kinase 3β (GSK3β) is a serine/threonine kinase and is considered as a validated target in osteosarcoma therapy.
|
29546355 |
2018 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
PP2A was a direct target of miR-21, which participated in the effects of ASBEL and miR-21 on the activation of phosphatidylinositol 3-kinase/protein kinase 3/glycogen synthase kinase-3β (PI3K/AKT/GSK3β) and mitogen-activated protein kinase/extracellular regulated protein kinase (MEK/ERK) signaling pathways as well as the enhancement of osteosarcoma cell proliferation, migration, and invasion.
|
29323740 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Moreover, AKT/GSK-3β pathway was measured to illustrate the mechanism of hsa_circ_0007534 exerts in OS progression.
|
30142548 |
2018 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
PPI induced inhibition of osteosarcoma cell viability was abolished upon addition of GSK-3β specific inhibitor, CHIR99021, while PPI induced inhibition of osteosarcoma cell viability and migration were potentiated by β-catenin silencing.
|
28790389 |
2017 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Inhibition of GSK-3β activity by pharmacological inhibitors or of its expression by RNA interference suppressed proliferation of osteosarcoma cells and induced apoptosis.
|
27780915 |
2016 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
However, the effect of GSK3β on HIF1α expression in osteosarcoma cells remains unknown.
|
24333432 |
2014 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Knockdown of TRPM8 by siRNA in osteosarcoma cells leads to the impaired regulation of intracellular Ca(2+) concentration and then the Akt-GSK-3β pathway and the phosphorylation of p44/p42 and FAK are suppressed.
|
24391455 |
2013 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The glycogen synthase kinase-3β/nuclear factor-kappa B pathway is involved in cinobufagin-induced apoptosis in cultured osteosarcoma cells.
|
23164673 |
2013 |
Osteosarcoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Silencing or pharmacological inhibition of GSK-3β resulted in apoptosis of osteosarcoma cells.
|
22534782 |
2012 |
Osteosarcoma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Celecoxib inhibited MG-63 cell viability, possibly by activating GSK-3β and inhibiting β-catenin-dependent gene transcription, suggesting a role for celecoxib in osteosarcoma treatment.
|
20926002 |
2010 |