|
AA amyloidosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Hereditary gelsolin amyloidosis (AGel amyloidosis) belongs to the wide group of amyloidotic diseases, which comprise various hereditary but also sporadic forms, such as inflammation-associated AA amyloidosis, primary or myeloma-associated AL amyloidosis and common Alzheimer's disease and type II diabetes-associated local amyloidoses.
|
19701715 |
2009 |
|
Abnormal spleen morphology
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Abnormality of abdomen morphology
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Acute Coronary Syndrome
|
0.300 |
Biomarker
|
disease |
CTD_human |
"Proteomic changes related to ""bewildered"" circulating platelets in the acute coronary syndrome."
|
21751358 |
2011 |
|
Acute pulmonary thromboembolism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, using mice model and recombinant human gelsolin (rhuGSN), we demonstrate the antithrombotic effect of gelsolin in ferric chloride induced thrombosis in carotid artery and thrombin induced acute pulmonary thromboembolism.
|
31002695 |
2019 |
|
Addictive Behavior
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Changes in drug use patterns reported on the web after the introduction of ADF OxyContin: findings from the Researched Abuse, Diversion, and Addiction-Related Surveillance (RADARS) System Web Monitoring Program.
|
28653782 |
2017 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Gelsolin protein and messenger RNA expressions were severely down-regulated in all adenocarcinomas tested.
|
18656242 |
2008 |
|
Adenocarcinoma
|
0.020 |
AlteredExpression
|
group |
BEFREE |
Additionally, pancreatic ductal adenocarcinomas displayed substantially decreased levels of gelsolin as judged by Western blot and immunohistochemical analyses of tissue micoarrays, when compared with cancerous and untransformed tissue from the same patients (P < 0.05).
|
18584046 |
2008 |
|
Adenocarcinoma of colon
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The aim of the present study was to evaluate the potential association between expression of β-catenin and gelsolin, and their influence on the migration ability of colon adenocarcinoma LS180 cells.
|
27798885 |
2016 |
|
Adenocarcinoma of colon
|
0.020 |
Biomarker
|
disease |
BEFREE |
Colon adenocarcinoma cell line LS180 was stably transfected with plasmid containing human cytoplasmic gelsolin cDNA tagged to enhanced green fluorescence protein (EGFP).
|
22552326 |
2012 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
In lung adenocarcinoma epithelial A549 cells, silencing of KEAP1 augmented the expression of peroxisome proliferator-activated receptor γ (PPARγ) and genes associated with cell differentiation, including E-cadherin and gelsolin.
|
22684020 |
2012 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Immunohistochemical staining in 20 paired LAC and adjacent normal tissues showed that IGKC, AAT, SH3BGRL3, osteopontin and gelsolin levels were higher in LAC tissues than in adjacent tissuesand were closely associated with LAC.
|
28404947 |
2017 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Our results therefore demonstrate that gelsolin down-regulation is an early and almost constant event in colon carcinogenesis and is associated with the transition from adenoma to carcinoma.
|
18656242 |
2008 |
|
Adenoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Moreover, gelsolin protein was down-regulated in a large proportion of high-grade adenomas (14/16) before the acquisition of invasive properties but in only a small proportion of low grade adenomas and serrated adenomas (2/30) and in none of the 9 cases of nonneoplastic hyperplastic polyps tested.
|
18656242 |
2008 |
|
Adenomatous Polyposis Coli
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
FAP is most commonly associated with variant plasma transthyretin (TTR), although it has also been described in association with mutant apolipoprotein A-1 and gelsolin.
|
8737931 |
1996 |
|
Adenomatous Polyposis Coli
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Familial amyloid polyneuropathy (FAP) is most commonly associated with variant plasma transthyretin, although it has also been described in association with mutant apolipoprotein A-1 and gelsolin.
|
8293178 |
1993 |
|
Adult Acute Myeloblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
To achieve this task, we evaluated the plasma gelsolin concentration in blood samples collected from patients diagnosed with acute myeloid leukemia (AML) at initial stages of sepsis.
|
30796880 |
2019 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The silencing of adenine nucleotide translocase isoform 1 induces oxidative stress and programmed cell death in ADF human glioblastoma cells.
|
20528917 |
2010 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
Using the ADF human glioblastoma and the M14 melanoma lines, and their derivative bcl-xL-overexpressing clones, we showed that the conditioned medium of bcl-xL transfectants increased in vitro endothelial cell functions, such as proliferation and morphogenesis, and in vivo vessel formation in Matrigel plugs, compared with the conditioned medium of control cells.
|
17699103 |
2007 |
|
Adult Glioblastoma
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
In this article, we investigated the effect induced by the reintroduction of wild-type p53 (wt-p53) protein on BCNU sensitivity in the ADF glioblastoma line.
|
10455409 |
1999 |
|
Adult Glioblastoma
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
With the aim to further evaluate the role of this enzyme in cell biology, we stably modulated its expression the human glioblastoma cell ADF in which the transient inhibition of cN-II has been shown to induce cell death.
|
26079827 |
2015 |
|
Adult Glioblastoma
|
0.050 |
Biomarker
|
disease |
BEFREE |
The basal caspase activity is accompanied by a constant cleavage of the motility-associated gelsolin protein, which may contribute to the caspase-mediated promotion of migration and invasiveness in glioblastoma cells.
|
18171980 |
2007 |
|
Adult Medulloblastoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Nineteen paired blood and MB DNA specimens from 16 patients (11 primary tumours, two primary with recurrent tumours, one primary tumour and cell line, two cell lines) were studied by PCR analysis of microsatellites at D9S55 (9p12), D9S15 (9q13-q21.1), D9S127 (9q21.1-21.3), D9S12 (9q22.3), D9S58 (9q22.3-q31), D9S109 (9q31), D9S53 (9q31), GSN (9q33), D9S60 (9q33-q34), D9S65 (9q33-q34), ASS (9q34), D9S67 (9q34.3), TH (11p15.5), D11S490 (11q23.3), D17S261 (17p11.2-12), D17S520 (17p12), TP53 (17p13.1), D17S5 (17p13.3), D17S515 (17q22-qter), and by RFLP analysis at the WT-1 locus (11p13).Only two tumours had LOH on 9q.
|
8208343 |
1994 |
|
Adult T-Cell Lymphoma/Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
ADF also enhanced IL 2-R expression of a rat T cell line transformed by HTLV-1(TARS-1), as demonstrated with anti-rat IL 2 receptor monoclonal antibodies (ART-18).
|
2999237 |
1985 |
|
Adult-onset immunodeficiency
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The results showed that the levels of haptoglobin in both active and inactive AOID groups were significantly higher than that in the control group, while the levels of gelsolin in the active AOID group were significantly lower than that in the inactive AOID group.
|
28647184 |
2017 |