|
Encephalitis, St. Louis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gelsolin: a new biomarker of disease activity in SLE patients associated with HDL-c.
|
31504936 |
2020 |
|
Lupus Erythematosus, Systemic
|
0.010 |
Biomarker
|
disease |
BEFREE |
Gelsolin: a new biomarker of disease activity in SLE patients associated with HDL-c.
|
31504936 |
2020 |
|
Bacterial Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Using the human keratinocyte cell line HaCaT stimulated by bacterially-derived LPS and LTA as an in vitro model of bacterial infection, we examined the anti-inflammatory effects of nanosystems consisting of iron oxide-based magnetic nanoparticles with aminosilane (MNP@NH<sub>2</sub>) or gold shells (MNP@Au) functionalized by a set of peptides, derived from the phosphatidylinositol 4,5-bisphosphate (PIP2)-binding site of the human plasma protein gelsolin, which also binds LPS and LTA.
|
30711007 |
2019 |
|
Cardiovascular Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
Gelsolin is the most abundant actin depolymerizing protein in plasma and its significantly depleted values have been reported in metabolic disorders including cardiovascular diseases and myocardial infarction.
|
31002695 |
2019 |
|
Mental Depression
|
0.010 |
Biomarker
|
disease |
BEFREE |
We show that gelsolin relocates from the dendritic shaft to dendritic spines upon cLTD induction while it did not show any relocalization upon cLTP induction.
|
31280237 |
2019 |
|
Adult Acute Myeloblastic Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
To achieve this task, we evaluated the plasma gelsolin concentration in blood samples collected from patients diagnosed with acute myeloid leukemia (AML) at initial stages of sepsis.
|
30796880 |
2019 |
|
Childhood Acute Myeloid Leukemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
To achieve this task, we evaluated the plasma gelsolin concentration in blood samples collected from patients diagnosed with acute myeloid leukemia (AML) at initial stages of sepsis.
|
30796880 |
2019 |
|
Airway constriction
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The gelsolin peptide also attenuated methacholine-induced airway constriction in murine precision-cut lung slices.
|
30407863 |
2019 |
|
Depressed mood
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
We show that gelsolin relocates from the dendritic shaft to dendritic spines upon cLTD induction while it did not show any relocalization upon cLTP induction.
|
31280237 |
2019 |
|
Pulmonary Thromboembolisms
|
0.010 |
Biomarker
|
disease |
BEFREE |
Overall, our studies provide conclusive evidence on the thrombo-protective role of plasma gelsolin in mice model of pulmonary thromboembolism and thrombosis.
|
31002695 |
2019 |
|
Hypoxic-Ischemic Encephalopathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Altered plasma-type gelsolin and amyloid-β in neonates with hypoxic-ischaemic encephalopathy under therapeutic hypothermia.
|
29466895 |
2019 |
|
Lewy Body Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, gelsolin may be considered a possible biomarker for the differentiation between DLB and AD.
|
31527695 |
2019 |
|
Respiratory Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
The purpose of this study was to determine if low plasma gelsolin independently predicts a reduced chance of weaning from ventilator-demanding respiratory failure in critically ill patients within 28 days from admission.
|
30339635 |
2019 |
|
Cardiac fibrosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Thus, we propose that along with its role in cardiac fibrosis, TGF-β also acts as an upstream activator of GSN dependent hypertrophy.
|
30240538 |
2019 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
Biomarker
|
disease |
BEFREE |
Finally, we identified gelsolin as a novel protein interaction partner of cortactin in PDAC.
|
30976201 |
2019 |
|
Acute pulmonary thromboembolism
|
0.010 |
Biomarker
|
disease |
BEFREE |
Here, using mice model and recombinant human gelsolin (rhuGSN), we demonstrate the antithrombotic effect of gelsolin in ferric chloride induced thrombosis in carotid artery and thrombin induced acute pulmonary thromboembolism.
|
31002695 |
2019 |
|
Cardiomyopathy, Dilated
|
0.010 |
Biomarker
|
group |
BEFREE |
Accordingly, loss of PI3Kα, the key PIP3-producing enzyme in the heart, increases gelsolin-mediated actin-severing activities in the myocardium in vivo, resulting in dilated cardiomyopathy in response to pressure-overload.
|
30568254 |
2018 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Distal ileum tissues from patients with CD had lower levels of VIL1 and GSN, increased phosphorylation of EIF2A, increased levels of IRGM and necroptosis, and increased release of nuclear DAMPs compared with controls.
|
29274870 |
2018 |
|
Fatigue
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The review will utilize results achieved using state-of-the-art aberration corrected transmission electron microscopy, including annular dark-field scanning transmission electron microscopy (ADF-STEM) and electron energy loss spectroscopy (EELS), showing how elemental discrimination can be achieved to understand structure at a deep level.
|
29974919 |
2018 |
|
Goiter
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
iTRAQ analysis of urinary proteins: Potential use of gelsolin and osteopontin to distinguish benign thyroid goiter from papillary thyroid carcinoma.
|
29355489 |
2018 |
|
Heart Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
PI3Kα-regulated gelsolin activity is a critical determinant of cardiac cytoskeletal remodeling and heart disease.
|
30568254 |
2018 |
|
HIV Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
New HIV infections were independently associated with ever using GSN apps to seek male sexual partners (P=.04) and in the past 3 months, using recreational drugs (P=.048), having group sex with males (P=.01), and having CAI with male CPs (P=.02).
|
30578225 |
2018 |
|
Kidney Failure, Acute
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Plasma gelsolin level predicts acute kidney injury after cardiopulmonary bypass in infants and young children.
|
29427164 |
2018 |
|
Cerebrovascular accident
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Higher levels of gelsolin and retinol-binding protein 4 were also found in the population with silent infarcts, both of which have been linked to stroke.
|
29545349 |
2018 |
|
Papillary thyroid carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
The data of the present study is suggestive of the potential application of urinary osteopontin and gelsolin to discriminate patients with BTG from those with PTC non-invasively.
|
29355489 |
2018 |