|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 may not be risk factors for oral cancer in the Jakarta population.
|
19469619 |
2009 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
GSTM1 null deletion was observed in 49% of oral cancer cases and 33% of control subjects.
|
11564581 |
2001 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our findings suggest that presence of GSTM1 and/or GSTT1 null genotypes along with variant alleles of CYP1A1 may be the risk alleles for oral cancer susceptibility in Pashtun population.
|
25735346 |
2015 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the GSTM1 null genotype may be associated with a higher risk of oral cancer in Asians but not in Caucasians, and this effect may be modified by smoking status.
|
21436184 |
2011 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The null variant of GSTM1 was associated with a marginally significant decrease in oral cancer risk [odds ratio (OR) = 0.6, 95% confidence interval (CI) = 0.3-1.0, and P for trend = 0.09].
|
15206494 |
2004 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The prevalence of the GSTM1 null genotypes was 29/87 (33.3%) and 21/40 (52.5%) in controls and oral cancer cases, respectively but the differences were not significant (OR=2.2; 95%CI=0.96-5.1; p=0.06).
|
16830058 |
2006 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The data suggest that variant genotypes of CYP1A1 might not be risk factors for oral cancer, whereas GSTM1 null genotype significantly increases susceptibility to oral cancer in Asians but not Caucasians.
|
19160101 |
2009 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid).
|
24102947 |
2014 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Differences in the GSTM1 and GSTT1 null genotype frequencies were observed between individuals of European origin and African origin, but these genotypes do not seem to influence the risk of oral cancer.
|
17418613 |
2008 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results suggest that the GSTM1 null and GSTM3 intron 6 polymorphisms play an important role in risk for oral cancer among African-Americans and implicates the mu class of GSTs as important tobacco carcinogen detoxifying enzymes in this population.
|
10762000 |
2000 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms of CYP2E1, GSTM1, and GSTT1; environmental factors and risk of oral cancer.
|
9367063 |
1997 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
For GSTM1 gene, null genotype appeared to be a risk factor for oral cancer (null vs present: OR 1.23, 95% CI 1.12-1.34), which was also proved in the subgroup analysis.The results demonstrated that CYP1A1 rs4646903 and null genotype of GSTM1 polymorphisms might serve as risk factors for oral cancer.
|
26166128 |
2015 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
GSTT1 null and rs1695 were inversely associated with oral leukoplakia while GSTM1 null, GSTT1 null, rs2031920, rs3813867 (CYP2E1), and rs13181 were associated with OC.
|
21741876 |
2011 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Aldehyde dehydrogenase 2 and glutathione S-transferase M 1 polymorphisms in relation to the risk for oral cancer in Japanese drinkers.
|
10889918 |
2000 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We discovered that GSTM1 deletion polymorphism had a significant effect on the susceptibility of oral cancer in the Indian population.
|
24528041 |
2014 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The results also suggested significant association between tobacco habits, especially chewing, variant genotypes of CYP1A1, GSTM1 and GSTT1 and oral cancer risk.
|
23444898 |
2014 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
These results suggest that the GSTM1 null genotype is not associated with oral cancer risk.
|
9332761 |
1997 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the meta-analysis suggests that GSTM1 null genotype is associated with increased risk of oral cancer in East Asians.
|
23801151 |
2013 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The results suggest that the GSTM1 null genotype is a risk factor for development of oral cancer among Indian tobacco habitues.
|
12016153 |
2002 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A significant risk increase for oral cancer was observed among subjects with the homozygous CYP1A1 (m2/m2) genotype (OR=3.8, 95% CI=1.9-7.7), but not the GSTM1 null genotype (OR=0.7, 95% CI=0.4-1.3).
|
17461521 |
2007 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.
|
19953622 |
2010 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here we determined the hot spot mutations in the D-loop region and revealing correlation if any, with clinical parameters, along with analysing the genetic polymorphism of GSTT1 and GSTM1 and its susceptibility towards oral cancer.
|
23265943 |
2013 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Only the coincidence of GSTM1 and GSTT null genotype was associated with oral cavity cancer.
|
12657030 |
2003 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
An association of oral squamous cell carcinoma (SCC) susceptibility with an MspI restriction site polymorphism of the CYP1A1 gene and GSTM1 polymorphism were reported in our previous study (Sato M, Sato T, Izumo T, Amagasa T. Genetic polymorphism of drug-metabolizing enzymes and susceptiblility to oral cancer.Carcinogenesis 1999;20:1927-31).
|
10793329 |
2000 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, this meta-analysis demonstrates that the GSTM1 null gene polymorphism may be an increased risk of oral cancer in Asians but not in Caucasians.
|
23900674 |
2014 |