|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our meta-analysis suggested that GSTM1 null genotype might be associated with an increased risk of developing oral cancer in individuals from Mainland China.
|
30539845 |
2018 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In total, 28 loci, that is, 14q32.33 (AKT1), 5q22.2 (APC), 11q22.3 (ATM), 2q33.1 (CASP8), 11q13.3 (CCND1), 16q22.1 (CDH1), 9p21.3 (CDKN2A), 1q31.1 (COX-2), 7p11.2 (EGFR), 22q13.2 (EP300), 4q35.2 (FAT1), 4q31.3 (FBXW7), 4p16.3 (FGFR3), 1p13.3 (GSTM1-GSTT1), 11q13.2 (GSTP1), 11p15.5 (H-RAS), 3p25.3 (hOGG1), 1q32.1 (IL-10), 4q13.3 (IL-8), 12p12.1 (KRAS), 12q15 (MDM2), 12q13.12 (MLL2), 9q34.3 (NOTCH1), 17p13.1 (p53), 3q26.32 (PIK3CA), 10q23.31 (PTEN), 13q14.2 (RB1), and 5q14.2 (XRCC4), were validated to be associated with oral cancer.
|
29037125 |
2017 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Preliminary Study of the GSTM1 Null Polymorphism and History of Tobacco Smoking among Oral Cancer Patients in Northeastern Thailand.
|
26925672 |
2016 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our findings suggest that presence of GSTM1 and/or GSTT1 null genotypes along with variant alleles of CYP1A1 may be the risk alleles for oral cancer susceptibility in Pashtun population.
|
25735346 |
2015 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
For GSTM1 gene, null genotype appeared to be a risk factor for oral cancer (null vs present: OR 1.23, 95% CI 1.12-1.34), which was also proved in the subgroup analysis.The results demonstrated that CYP1A1 rs4646903 and null genotype of GSTM1 polymorphisms might serve as risk factors for oral cancer.
|
26166128 |
2015 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The impact of GSTM1/GSTT1 polymorphism for the risk of oral cancer.
|
25595865 |
2015 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid).
|
24102947 |
2014 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
We discovered that GSTM1 deletion polymorphism had a significant effect on the susceptibility of oral cancer in the Indian population.
|
24528041 |
2014 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The results also suggested significant association between tobacco habits, especially chewing, variant genotypes of CYP1A1, GSTM1 and GSTT1 and oral cancer risk.
|
23444898 |
2014 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, this meta-analysis demonstrates that the GSTM1 null gene polymorphism may be an increased risk of oral cancer in Asians but not in Caucasians.
|
23900674 |
2014 |
|
Malignant neoplasm of mouth
|
0.100 |
Biomarker
|
group |
BEFREE |
We found that the size of study sample varied greatly and the oral cavity cancer was more influenced by GSTM1 and GSTT1 gene deletions.
|
23886141 |
2013 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the meta-analysis suggests that GSTM1 null genotype is associated with increased risk of oral cancer in East Asians.
|
23801151 |
2013 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Here we determined the hot spot mutations in the D-loop region and revealing correlation if any, with clinical parameters, along with analysing the genetic polymorphism of GSTT1 and GSTM1 and its susceptibility towards oral cancer.
|
23265943 |
2013 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In conclusion, the GSTM1 null genotype may be associated with a higher risk of oral cancer in Asians but not in Caucasians, and this effect may be modified by smoking status.
|
21436184 |
2011 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
GSTT1 null and rs1695 were inversely associated with oral leukoplakia while GSTM1 null, GSTT1 null, rs2031920, rs3813867 (CYP2E1), and rs13181 were associated with OC.
|
21741876 |
2011 |
|
Malignant neoplasm of mouth
|
0.100 |
Biomarker
|
group |
BEFREE |
Polymorphisms in the encoding genes (CYP1A1, GSTM1, GSTT1 and GSTP1) potentially may therefore contribute towards risk association for oral cancer.
|
21545219 |
2011 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.
|
19953622 |
2010 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 may not be risk factors for oral cancer in the Jakarta population.
|
19469619 |
2009 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The data suggest that variant genotypes of CYP1A1 might not be risk factors for oral cancer, whereas GSTM1 null genotype significantly increases susceptibility to oral cancer in Asians but not Caucasians.
|
19160101 |
2009 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Individuals carrying the deletions of GSTM1 and GSTT1 are at high risk of developing oral cancers.
|
19718946 |
2009 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Telomere attrition and telomerase activity are associated with GSTM1 polymorphism in oral cancer.
|
19729828 |
2009 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Differences in the GSTM1 and GSTT1 null genotype frequencies were observed between individuals of European origin and African origin, but these genotypes do not seem to influence the risk of oral cancer.
|
17418613 |
2008 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Individuals with GSTM1 null genotype may be at higher risk of oral cancer development.
|
18838881 |
2008 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
A significant risk increase for oral cancer was observed among subjects with the homozygous CYP1A1 (m2/m2) genotype (OR=3.8, 95% CI=1.9-7.7), but not the GSTM1 null genotype (OR=0.7, 95% CI=0.4-1.3).
|
17461521 |
2007 |
|
Malignant neoplasm of mouth
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The prevalence of the GSTM1 null genotypes was 29/87 (33.3%) and 21/40 (52.5%) in controls and oral cancer cases, respectively but the differences were not significant (OR=2.2; 95%CI=0.96-5.1; p=0.06).
|
16830058 |
2006 |