|
Abdominal Neoplasms
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This protective effect mediated by the presence of GSTM1 was even more pronounced within the subset of therapy group B patients at highest clinical risk of treatment failure (B-ALL, disease stage IV, disease stage III with unresected abdominal tumor, and LDH activity > or = 500 U/L).
|
12091121 |
2002 |
|
Acquired aplastic anemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
Increased frequencies of glutathione S-transferase (GSTM1 and GSTT1) gene deletions in Korean patients with acquired aplastic anemia.
|
11719393 |
2001 |
|
Acquired aplastic anemia
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
We analyzed the impact of the polymorphisms in CYP4501A1 and GSTM1 and GSTT1 genes on the susceptibility and disease severity in 200 patients with AA and compared the frequency with the normal population.
|
16227674 |
2005 |
|
Acquired sensorineural hearing loss
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Association of Glutathione s-transferase M1 and T1 gene polymorphisms with the susceptibility to acquired sensorineural hearing loss: a systematic review and meta-analysis.
|
30696891 |
2019 |
|
Actinic cheilitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A case-control study of 164 lung adenocarcinoma (AC) patients with 181 age- and gender-matched healthy controls was conducted in order to assess any associations between glutathione-S-transferase M1 (GSTM1), cytochrome P4501A1 (CYP1A1) and cytochrome P4502E1 (CYP2E1) polymorphisms and susceptibility to lung AC in Chinese.
|
12824892 |
2003 |
|
Actinic keratosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
To verify the possible association between the development of SK and the 'null' GSTM1 and/or T1 genotype.
|
19874347 |
2010 |
|
Actinic keratosis
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 null genotype confers an increased risk for solar keratosis development in an Australian Caucasian population.
|
12485442 |
2002 |
|
Acute Chest Syndrome
|
0.020 |
Biomarker
|
disease |
BEFREE |
The absence of GSTT1 and/or GSTM1 was an important risk factor for increasing the morbidity of SCA, especially in regard to acute chest syndrome.
|
23590899 |
2013 |
|
Acute Chest Syndrome
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 null genotype was significantly associated with ACS and VOC (P = 0.03 and 0.01, respectively).
|
25880856 |
2015 |
|
Acute hepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with a history of anti-TB drug-induced acute hepatitis (cases with an increase to 3 times the upper limit of normal serum transaminases and symptoms of hepatitis) and patients with no evidence of anti-TB hepatic side effects (controls) were genotyped for NAT2, CYP2E1, GSTM1 and GSTT1 polymorphisms.
|
22012226 |
2011 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
When the OR used to determine statistical power was lowered to 1.2, 2 of the 4 noteworthy associations remained so: GSTM1 null with bladder cancer and acute leukemia.
|
18505952 |
2008 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results suggested that the GSTM1 null genotype and GSTT1null genotype, but not the GSTP1 polymorphism, might be a potential risk factors for acute leukemia.
|
24716937 |
2014 |
|
Acute leukemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Role of CYP2D6, CYP1A1, CYP2E1, GSTT1, and GSTM1 genes in the susceptibility to acute leukemias.
|
16493615 |
2006 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Deletion of GSTM1 and T1 genes as a risk factor for development of acute leukemia.
|
23725116 |
2013 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis supports that GSTM1 null polymorphism is capable of causing childhood acute leukemia susceptibility.
|
24194954 |
2013 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTM1-null genotype was associated with a lower risk of developing acute leukemia (P = 0.013; OR: 0.31; CI: 0.12-0.80), while GSTP1-GG variants displayed an increased risk (P = 0.01; OR: 3.9; CI: 1.85-8.2).
|
25799091 |
2015 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, the GSTM1 null genotype was significantly associated with increased risk of childhood acute leukemia in Chinese (fixed effect OR = 2.49; 95% CI, 1.84–3.37; P < 0.001).
|
24022662 |
2014 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals carrying null GSTTI and GSTM1 genotypes had a 1.52- and 1.78-fold increased risk of developing acute leukemia, respectively, compared to non-null genotype carriers (P < 0.05).
|
24854448 |
2014 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Glutathione s-transferase polymorphisms (GSTM1, GSTP1 and GSTT1) and the risk of acute leukaemia: a systematic review and meta-analysis.
|
15862746 |
2005 |
|
Acute leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This case-control study suggests a contribution of CYP2D6 and GSTM1 null variants in the development of acute leukaemia.
|
17581325 |
2007 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When NAT2 slow acetylators were considered together with the other risk-elevating genotypes, GSTM1 null and CYP1A1*2A, the risk of ALL increased further, which showed that the combination of these genotypes is more predictive of risk then either of them independently.
|
10868688 |
2000 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The odds ratios for both GSTM1 and GSTT1 deletions being associated with ALL was 2.78 (95% CI = 0.67-11.56).
|
15382273 |
2004 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A combination between GSTM1 double-null genotype and rs1695 also showed an association with ALL (P=0.042).
|
27299594 |
2016 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When combined with other GST genotypes, we found that the combination of GSTP1*B and GSTM1 null genotypes further increased the risk of ALL (OR = 2.1; 95% CI-1.3-3.4).
|
12439226 |
2002 |
|
Acute lymphocytic leukemia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our results suggest that the combined gene dose of GSTM1 and GSTT1 may influence outcome in childhood ALL.
|
22215096 |
2012 |