|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This might constitute the first step towards identifying polymorphism combinations that predispose to endometriosis (IFNG (CA) repeat, GSTM1 null genotype, GSTP1 rs1695, WNT4 rs16826658 and WNT4 rs2235529) in a large cohort of patients with well-defined inclusion criteria.
|
31821471 |
2020 |
|
Endometriosis
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Methylation levels of the GSTM1 promoter region in the ectopic and eutopic endometrial tissues of patients with ovarian endometriosis and the endometrial tissues of women without endometriosis were analysed by pyrosequencing.
|
30989213 |
2019 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, increased endometriosis risk was associated with carrying the C allele of CYP1A1 combined with GSTM1 null genotypes.
|
27525656 |
2016 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our meta-analysis supports that the GSTM1/GSTT1 null genotype might contribute to individual susceptibility to endometriosis in Chinese populations, especially in Chinese Han.
|
26370772 |
2015 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymerase chain reaction was performed to analyze the GSTM1 and GSTT1 genotypes among women with surgically and histologically confirmed endometriosis (case group n = 121) and in women without evidence of endometriosis confirmed by laparoscopy for investigation the infertility or for laparoscopic tubal sterilization (control group n = 97).
|
26350109 |
2015 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The findings suggest that the GSTM1 and GSTT1 gene deficiency predisposes to endometriosis in a Tunisian population and can confer a significant increased risk when the GST null genotypes are combined.
|
25549292 |
2015 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we found a significant positive association between the dual null genotype GSTM1-GSTT1 and endometriosis susceptibility (OR = 1.33, 95% CI: 1.03-1.72, P = 0.027).
|
25208225 |
2014 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The contributions of GSTM1 and GSTT1 polymorphisms to the proliferation of endometriosis were not statistically significant, but the analysis of pathology and the association of GSTM1 and GSTT1 gene polymorphisms with p53 codon 72 revealed statistical significance.
|
23979901 |
2013 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the single SNP analysis, GSTM1 null type and AhRR variant type were associated with a significantly increased risk of endometriosis [odds ratio (OR)=2.38 and 2.45, respectively].
|
22017422 |
2012 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We evaluated the relationship between common genetic variation and endometriosis risk, using gene-based tests and single-variant analysis of genetic polymorphisms in ESR1, ESR2, PGR, CYP17A1, CYP19A1, HSD17B1, HSD17B2, CYP1A1, CYP1A2, COMT, and GSTM1.
|
21958689 |
2011 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, the relationship between GSTM1 genotypes and endometriosis in an Iranian population was investigated.
|
20504102 |
2011 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Association between phthalate exposure and glutathione S-transferase M1 polymorphism in adenomyosis, leiomyoma and endometriosis.
|
20147336 |
2010 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The association between the concentrations of PCBs, GSTM1 null genotype and different severity of endometriosis was significant (P<0.05) for all four compounds and GSTM1 (PCB1: r = +0.5388, P<0.0001; PCB5: r = +0.6753, P<0.0001; PCB29: r = +0.6471, P<0.0001; and PCB98: r = +0.4357, P<0.0001; GSTM1: r = +0.9439, P = 0.05).
|
19535834 |
2009 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study was performed to determine whether genetic polymorphisms of aryl hydrocarbon receptor repressor (AhRR), glutathione-S-transferase M1 (GSTM1) and glutathione-S-transferase T1 (GSTT1) are associated with susceptibility to advanced stage endometriosis in a Korean population.
|
17513317 |
2007 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study was to investigate whether the polymorphisms of GSTM1, GSTT1 and GSTP1 are related to endometriosis.
|
15531593 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed an association between endometriosis and the GSTM1 null deletion, but not with GSTT1 null deletions or the CYP1A1 MspI polymorphism in South Indian women.
|
15861041 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many studies have investigated the role of GSTM1 and GSTT1 gene polymorphisms in endometriosis.
|
15878920 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After correction for this bias, there is no evidence that women with GSTM1 null genotype have increased risk of developing endometriosis as compared with women with other genotypes.
|
16291859 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
No evidence was found to suggest an association between GSTM1-null genotype and endometriosis in the Hans and Uygurs.
|
15059587 |
2004 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Allelic variants of GSTM1 and MPO gene polymorphisms might impair detoxification function and increase the susceptibility to endometriosis.
|
15299090 |
2004 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 and GSTT1 null genotypes may be risk factors for the development of endometriosis.
|
12875700 |
2003 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest that CYP19 VNTR (TTTA)(10) allele as well as the combined genotype CYP1A1 m1 polymorphism and GSTM1 null deletion associate with the endometriosis phenotype, whereas the GSTT1 null deletion does not.
|
12620480 |
2003 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combination of CYP1A1 m1 polymorphism and GSTM1 null deletion is closely associated with penetration of the endometriosis phenotype, whereas GSTT1 null deletion may add to the penetration of this trait.
|
11730751 |
2001 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, the combination of the GSTM1 null genotype and the CYP1A1 MspI polymorphism was associated with a small increased risk of endometriosis, and this warrants further investigation.
|
11675474 |
2001 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The frequency of the GSTM1 null allele was not over-represented in the endometriosis patients (47.6%) compared with the controls (48.9%) (P = 0.898).
|
11159742 |
2001 |