|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
As Gstm1 plays an important role in the secondary defence against oxidative stress, significantly lower expression levels may be functionally relevant in the development of hypertension.
|
30308595 |
2019 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In addition, I<sup>2</sup> > 75% cannot be eliminated for GSTM1 in Indians or Asians, hence, it will be very important to explore the GSTM1 null-genotype and hypertension susceptibility in Indians and Asians for a large new sample, on population-based control study.
|
30420646 |
2019 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
BEFREE |
Combined Effects of GSTM1 Null Allele and APOL1 Renal Risk Alleles in CKD Progression in the African American Study of Kidney Disease and Hypertension Trial.
|
26940095 |
2016 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In order to drive a more precise estimation, the present systematic review and meta-analysis is performed to investigate the relationship between the GSTM1 and GSTT1 null polymorphisms and hypertension.
|
25742618 |
2015 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
It is concluded that ACE (rs 4646994), FABP2 (rs1799883) and GST (GSTM1 null or positive genotype and GSTT1 null or positive genotype) genes polymorphism are associated with HTN.
|
25357227 |
2015 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Absence of both GSTM1 and GSTT1 genes was significantly associated with pulmonary hypertension (P = 0.04).
|
25880856 |
2015 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Meta-analysis revealed significant associations between the null genotypes of GSTM1 (OR: 1.22; 95% CI: 1.08-1.39; p=0.002) and GSTT1 (OR: 1.30; 95% CI: 1.13-1.50; p=0.0003) and risk of hypertension.
|
24788870 |
2014 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The adjusted OR for CP presence (adjusted for age, gender, smoking, hypertension, BMI, HDLC, TG) was 0.24, 95 %CI 0.08-0.7, p < 0.01 for GSTT1 null and 1.13, 95 %CI 0.62-2.07, p = 0.7 for GSTM1 null genotype.
|
24407598 |
2014 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
GSTM1-null and GSTT1-null genotypes are associated with essential arterial hypertension in patients with type 2 diabetes.
|
24685594 |
2014 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
A weak association was observed between the GSTM1 genetic polymorphism and family history of hypertension.
|
22108414 |
2011 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Association between the GSTM1 null genotype and hypertension was significant in younger subjects.
|
21728793 |
2011 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
This study showed that GSTT1 and GSTM1 null genotypes, together with hypertension, may play a significant role in the pathogenesis of ischemic stroke.
|
20517701 |
2010 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
In the current study, allelic polymorphisms of GSTM1 and GSTT1 were analyzed in three ethnic groups of North East (NE) India where a high prevalence of various cancers and other diseases such as hypertension, tuberculosis, and asthma have been reported.
|
20073549 |
2010 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We investigated a possible association between hypertension and haptoglobin, angiotensin I-converting enzyme (ACE), glutathione S-transferases GSTM1 and GSTT1, MnSOD (Val9Ala), CAT (-21A/T), and GPX1 (Pro198Leu) gene polymorphisms in an urban Brazilian population group from Brasília.
|
21053180 |
2010 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Similarly, among smokers with GSTM1-null genotype, levels of 4-aminobiphenyl-hemoglobin adducts were significantly lower among untreated hypertensive individuals (45.7 pg/g Hb) compared with individuals without hypertension (79.8 pg/g Hb) (P = 0.009).
|
20732908 |
2010 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
GSTM1-null individuals (n=156) were significantly associated with increased risk of hypertension [OR=2.25 (1.36-3.72); p=0.005].
|
18840420 |
2009 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
Null GSTM1 genotype occurred more frequent in patients with resistant hypertension than those with controlled hypertension (57.1 vs 39.7%; P=0.03; RR 1.96; 95% CI 1.04-3.69) suggesting that null GSTM1 genotype may predispose to resistant hypertension.
|
19279659 |
2009 |
|
Hypertensive disease
|
0.300 |
AlteredExpression
|
group |
BEFREE |
These results suggest that reduced Gstm1 expression in SHRSPs is due to strain-dependent genetic abnormalities, playing a causative role in the development of hypertension, probably through oxidative stress pathway.
|
19531963 |
2009 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
We then genotyped 753 trios from the Medical Research Council British Genetics of Hypertension Study transmission disequilibrium test cohort for 10 single nucleotide polymorphisms and the GSTM1 deletion and examined renal GSTM expression in a cohort of 27 hypertensive and 18 normotensive subjects.
|
18551009 |
2008 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The risk of hypertension was significantly increased in the GSTA1*B allele carriers having also the GSTM1 null genotype or both the GSTM1 and GSTT1 null genotypes (adjusted OR: 2.4; 95% CI: 1.2-4.9; adjusted OR: 3.1; 95% CI: 1.0-9.5, respectively).
|
18300949 |
2008 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
LHGDN |
The risk of hypertension was significantly increased in the GSTA1*B allele carriers having also the GSTM1 null genotype or both the GSTM1 and GSTT1 null genotypes (adjusted OR: 2.4; 95% CI: 1.2-4.9; adjusted OR: 3.1; 95% CI: 1.0-9.5, respectively).
|
18300949 |
2008 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
BEFREE |
The aim of this study is to investigate GSTM1, GSTT1 and MTHFR genetic polymorphisms and its relation with total plasma glutathione (tGSH) levels in hypertension.
|
17182005 |
2007 |
|
Hypertensive disease
|
0.300 |
GeneticVariation
|
group |
LHGDN |
The aim of this study is to investigate GSTM1, GSTT1 and MTHFR genetic polymorphisms and its relation with total plasma glutathione (tGSH) levels in hypertension.
|
17182005 |
2007 |
|
Hypertensive disease
|
0.300 |
Biomarker
|
group |
RGD |
Reduction of Gstm1 expression in the stroke-prone spontaneously hypertension rat contributes to increased oxidative stress.
|
15699453 |
2005 |