|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The glutathione S-transferase mu 1 (<i>GSTM1</i>) null genotype decreased EC risk (OR=0.510).
|
31423187 |
2019 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Analyses of the GSTM1 polymorphisms demonstrated that there was a significantly increased EC risk in GSTM1 null genotype carriers (OR = 1.319, 95% CI = 1.125-1.546, p for heterogeneity <0.001).
|
29215312 |
2018 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 null polymorphism may be associated with an increased risk for EC in Asian but not Caucasian populations.
|
26855551 |
2016 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, we assessed the association of functional polymorphisms in GSTM1 and GSTT1 with esophageal cancer in Kashmir, India, an area with a high incidence of esophageal squamous cell carcinoma (ESCC).
|
25432134 |
2015 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, CYP1A1 and GSTM1 gene polymorphisms affect familial aggregation of EC among the Kazakh ethnic group in Xinjiang.
|
26782562 |
2015 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of those 18 studies showed that GSTM1 null genotype was associated with an increased risk of esophageal carcinoma in Chinese (random effect model OR = 1.49, 95 %CI = 1.11-2.00, P = 0.008).
|
23625656 |
2013 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant association of GSTM1 null genotype with esophageal cancer was observed in a younger age group in Assam (OR-2.7, 95 % CI, 1.48-5.01), and in Delhi population association was observed in smokers with GSTT1 null genotype (OR-2.5, 95 % CI, 1.04-6.07), and alcoholics having GSTM1 null genotype (OR-2.6, 95 % CI, 0.99-6.77).
|
23749488 |
2013 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results showed that GSTM1 null genotype and GSTT1 null genotype were significantly associated with increased risk for esophageal cancer in Chinese population.
|
20391126 |
2010 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of GSTM1, GSTT1 and GSTP1 in association with some environmental factors and their impact on esophageal cancer susceptibility were assessed in the Iranian population.
|
20409775 |
2010 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A case-control study was performed in 135 EC patients and 195 healthy controls to analyze association of polymorphisms in glutathione S-transferase (GST) mu (GSTM1), GST theta (GSTT1), GST pi (GSTP1), GSTM3, Cytochrome P450 (CYP)1A1, and CYP2E1 genes with susceptibility to EC as well as their interaction with environmental factors such as smoking and high consumption of salted tea in Kashmir valley.
|
20661821 |
2010 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We undertook this study to assess possible associations of esophageal cancer risk with CYP1A1 genetic variation and GSTM1 null genotype, respectively.
|
19427967 |
2009 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms of GSTP1 and GSTT1, but not of CYP2A6, CYP2E1 or GSTM1, modify the risk for esophageal cancer in a western population.
|
17916905 |
2007 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Glutathione-S-transferase M1 polymorphisms on the susceptibility to esophageal cancer among three Chinese minorities: Kazakh, Tajik and Uygur.
|
17203516 |
2006 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In patients with smoking habits, GSTM1 null and GSTP1 ile/ile genotype were at higher risk for esophageal cancer (OR 1.5; 95% CI=0.50-4.4 and OR 1.3; 95% CI=0.40-3.5), respectively.
|
16338071 |
2006 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Gene-environment interaction analysis showed that CYP1A1 Val/Val genotype, GSTM1 deletion genotype had synergetic interactions with tobacco smoking, alcohol drinking and family history of EC.
|
15052670 |
2004 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest the GSTM1 polymorphism is involved in the susceptibility to esophageal cancer development, and tea consumption reduces the risk of esophageal and stomach cancers.
|
12406553 |
2002 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Relationship of tobacco smoking CYP1A1 GSTM1 gene polymorphism and esophageal cancer in Xi'an.
|
11833070 |
2002 |
|
Esophageal carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results are consistent with the notion that exposure to environmental carcinogens that are detoxified by GSTM1, such as polycyclic aromatic hydrocarbons, may contribute to the etiology of esophageal cancer in Linxian.
|
10840162 |
2000 |
|
Esophageal carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We studied the frequencies of polymorphic variants in CYP1A1, GSTP1, GSTT1, and GSTM1 genes in 98 patients with Barrett's epithelium and 34 patients with esophageal cancer.
|
9973204 |
1999 |
|
Esophageal carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Specific genotypes of the CYP1A1 and GSTM1- genes are related to the incidence of esophageal carcinoma, especially in heavy smokers.
|
9307183 |
1997 |
|
Esophageal carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We investigated the genetic polymorphisms of CYP1A1, CYP2E1 and GSTM1 in Japanese esophageal cancer patients (n = 53) with a histological diagnosis of squamous-cell carcinoma, to determine whether susceptibility to esophageal cancer is associated with these polymorphisms.
|
9139841 |
1997 |