|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our meta-analysis suggested that GSTM1 null genotype might be associated with an increased risk of developing oral cancer in individuals from Mainland China.
|
30539845 |
2018 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In total, 28 loci, that is, 14q32.33 (AKT1), 5q22.2 (APC), 11q22.3 (ATM), 2q33.1 (CASP8), 11q13.3 (CCND1), 16q22.1 (CDH1), 9p21.3 (CDKN2A), 1q31.1 (COX-2), 7p11.2 (EGFR), 22q13.2 (EP300), 4q35.2 (FAT1), 4q31.3 (FBXW7), 4p16.3 (FGFR3), 1p13.3 (GSTM1-GSTT1), 11q13.2 (GSTP1), 11p15.5 (H-RAS), 3p25.3 (hOGG1), 1q32.1 (IL-10), 4q13.3 (IL-8), 12p12.1 (KRAS), 12q15 (MDM2), 12q13.12 (MLL2), 9q34.3 (NOTCH1), 17p13.1 (p53), 3q26.32 (PIK3CA), 10q23.31 (PTEN), 13q14.2 (RB1), and 5q14.2 (XRCC4), were validated to be associated with oral cancer.
|
29037125 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Preliminary Study of the GSTM1 Null Polymorphism and History of Tobacco Smoking among Oral Cancer Patients in Northeastern Thailand.
|
26925672 |
2016 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For GSTM1 gene, null genotype appeared to be a risk factor for oral cancer (null vs present: OR 1.23, 95% CI 1.12-1.34), which was also proved in the subgroup analysis.The results demonstrated that CYP1A1 rs4646903 and null genotype of GSTM1 polymorphisms might serve as risk factors for oral cancer.
|
26166128 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The impact of GSTM1/GSTT1 polymorphism for the risk of oral cancer.
|
25595865 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that presence of GSTM1 and/or GSTT1 null genotypes along with variant alleles of CYP1A1 may be the risk alleles for oral cancer susceptibility in Pashtun population.
|
25735346 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Among these 14 variants, 9 variants were reported to be significantly associated with the risk of oral cancer (CYP1A1-MspI, CYP2E1-RsaI/PstI, MTHFR-C677T, p73-G4C14-to-A4T14, XRCC1-Arg194Trp, CYP1A1-Ile462Val, GSTM1-±, and NAT2 slow vs rapid).
|
24102947 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results also suggested significant association between tobacco habits, especially chewing, variant genotypes of CYP1A1, GSTM1 and GSTT1 and oral cancer risk.
|
23444898 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We discovered that GSTM1 deletion polymorphism had a significant effect on the susceptibility of oral cancer in the Indian population.
|
24528041 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this meta-analysis demonstrates that the GSTM1 null gene polymorphism may be an increased risk of oral cancer in Asians but not in Caucasians.
|
23900674 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we determined the hot spot mutations in the D-loop region and revealing correlation if any, with clinical parameters, along with analysing the genetic polymorphism of GSTT1 and GSTM1 and its susceptibility towards oral cancer.
|
23265943 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the meta-analysis suggests that GSTM1 null genotype is associated with increased risk of oral cancer in East Asians.
|
23801151 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTT1 null and rs1695 were inversely associated with oral leukoplakia while GSTM1 null, GSTT1 null, rs2031920, rs3813867 (CYP2E1), and rs13181 were associated with OC.
|
21741876 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, the GSTM1 null genotype may be associated with a higher risk of oral cancer in Asians but not in Caucasians, and this effect may be modified by smoking status.
|
21436184 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms in the encoding genes (CYP1A1, GSTM1, GSTT1 and GSTP1) potentially may therefore contribute towards risk association for oral cancer.
|
21545219 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.
|
19953622 |
2010 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Telomere attrition and telomerase activity are associated with GSTM1 polymorphism in oral cancer.
|
19729828 |
2009 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 may not be risk factors for oral cancer in the Jakarta population.
|
19469619 |
2009 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The data suggest that variant genotypes of CYP1A1 might not be risk factors for oral cancer, whereas GSTM1 null genotype significantly increases susceptibility to oral cancer in Asians but not Caucasians.
|
19160101 |
2009 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals with GSTM1 null genotype may be at higher risk of oral cancer development.
|
18838881 |
2008 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Differences in the GSTM1 and GSTT1 null genotype frequencies were observed between individuals of European origin and African origin, but these genotypes do not seem to influence the risk of oral cancer.
|
17418613 |
2008 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
A significant risk increase for oral cancer was observed among subjects with the homozygous CYP1A1 (m2/m2) genotype (OR=3.8, 95% CI=1.9-7.7), but not the GSTM1 null genotype (OR=0.7, 95% CI=0.4-1.3).
|
17461521 |
2007 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The prevalence of the GSTM1 null genotypes was 29/87 (33.3%) and 21/40 (52.5%) in controls and oral cancer cases, respectively but the differences were not significant (OR=2.2; 95%CI=0.96-5.1; p=0.06).
|
16830058 |
2006 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 null alone or associated with CYP1A1 increased the risk of head and neck cancer; the CYP2E1PstI mutated allele increased the risk for only oral cancer.
|
16721740 |
2006 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The null variant of GSTM1 was associated with a marginally significant decrease in oral cancer risk [odds ratio (OR) = 0.6, 95% confidence interval (CI) = 0.3-1.0, and P for trend = 0.09].
|
15206494 |
2004 |