cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although no significant links were found between GST polymorphism and treatment response, null genotypes of GSTM1, GSTT1 and 'G' allele of GSTP1 bring a higher risk of severe gastrointestinal toxicity due to chemoradiation therapy in cervical cancer.
|
29909733 |
2018 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 null genotype and susceptibility to cervical cancer in the Chinese population: An updated meta-analysis.
|
27461638 |
2017 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lack of participation of the GSTM1 polymorphism in cervical cancer development in Northeast Thailand.
|
25773790 |
2015 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk of cervical cancer was almost three times in women with GSTM1 homozygous null genotype (OR-2.62, 95%CI, 1.77-3.88; p<0.0001).
|
26434855 |
2015 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that smokers with null GSTM1 genotype had higher risk of cervical cancer (OR = 2.27, 95%CI, 1.46-3.54).
|
24391774 |
2013 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that smokers with null GSTM1 genotype had a moderate increased risk of cervical cancer (OR=1.85, 95% CI=1.07-3.20).
|
22631654 |
2012 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results showed that smokers with null GSTM1 genotype had higher risk of cervical cancer (OR=1.56, 95%CI=1.01-2.41).
|
22575983 |
2012 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
For the GSTM1 polymorphism, the null genotype of GSTM1 was associated with an increased CC risk in total population (OR=1.32, 95% CI=1.06-1.66).
|
21520994 |
2011 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 null genotype confers additional risk for cervical cancer in non-Chinese populations.
|
21150818 |
2010 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of GSTM1 and GSTT1 were not significant risk factors for cervical cancer in either tobacco-smokers or non-smokers.
|
19640174 |
2009 |
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Blood samples from 150 women with biopsy-confirmed cervical cancer and 168 healthy controls were analyzed by multiplex polymerase chain reaction (PCR) to detect the presence or absence of GSTM1 and GSTT1.
|
18177825 |
2008 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Cigarette smoking and glutathione S-transferase M1 polymorphism associated with risk for uterine cervical cancer.
|
19012698 |
2008 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
On individual analysis of GSTM1, GSTT1, and GSTP1, it was observed that passive smokers having genotypes GSTM1 (null) (OR = 7.0, 95% CI = 2.19-22.36, P = 0.0005), GSTT1 (null) (OR = 10.2, 95% CI = 1.23-84.18, P = 0.02), and GSTP1 (ile/val) (OR = 6.4, 95% CI = 2.25-18.38, P = 0.0005) have an increased risk of developing cervix cancer.
|
16631467 |
2006 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results suggest that polymorphisms in the CYP1A1, GSTM1 and GSTT1 genes may render women more susceptible to the development of cervical cancer.
|
16360200 |
2006 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In this study, genetic polymorphisms, NQO1 C609T, GSTM1 positive/null, and GSTT1 positive/null, were examined with reference to cervical cancer risk in a population-based incident case-control study in Japanese.
|
15661231 |
2005 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
From genetic susceptibility factors, polymorphisms in the CYP2E1 and mEH genes are not associated with CC but the GSTM1 null genotype is for the US population.
|
15138035 |
2004 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Further, the combined analysis of both GSTM1 null and GSTT1 null genotypes did not appear to influence the susceptibility to cervical cancer, suggesting that polymorphisms of other detoxifying enzymes may play a significant role in cervical carcinogenesis.
|
15004652 |
2004 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although the GSTM1 and GSTT1 genotype was not significantly associated with cervical cancer development for all women, the GSTM1 null genotype was significantly associated with an increased risk of cervical cancer development in women with high-risk HPV infection (OR = 2.9, 95% CI: 1.0-8.2).
|
15047208 |
2004 |
cervical cancer
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our study suggests that genetic differences in the metabolism of cigarette smoke, particularly GSTM1, may confer susceptibility to CC.
|
12552594 |
2003 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data suggest that women with the GSTM1 null genotype are not at increased risk of cervical cancer.
|
10489995 |
1999 |
cervical cancer
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Progression of cervical intraepithelial neoplasia to cervical cancer: interactions of cytochrome P450 CYP2D6 EM and glutathione s-transferase GSTM1 null genotypes and cigarette smoking.
|
7917923 |
1994 |