GSTM2, glutathione S-transferase mu 2, 2946

N. diseases: 195; N. variants: 11
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0270715
Disease: Degenerative Diseases, Central Nervous System
Degenerative Diseases, Central Nervous System 		0.300 Biomarker group CTD_human Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. 15964507 2005
CUI: C0751733
Disease: Degenerative Diseases, Spinal Cord
Degenerative Diseases, Spinal Cord 		0.300 Biomarker group CTD_human Pharmacogenomic profiling of an oxidative stress-mediated spongiform encephalopathy. 15964507 2005
CUI: C0013080
Disease: Down Syndrome
Down Syndrome 		0.300 Biomarker disease CTD_human Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome. 11771762 2001
CUI: C0432416
Disease: Down Syndrome, Partial Trisomy 21
Down Syndrome, Partial Trisomy 21 		0.300 Biomarker disease CTD_human Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome. 11771762 2001
CUI: C0432417
Disease: Trisomy 21, Meiotic Nondisjunction
Trisomy 21, Meiotic Nondisjunction 		0.300 Biomarker disease CTD_human Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome. 11771762 2001
CUI: C0751081
Disease: Trisomy 21, Mitotic Nondisjunction
Trisomy 21, Mitotic Nondisjunction 		0.300 Biomarker disease CTD_human Antioxidant proteins in fetal brain: superoxide dismutase-1 (SOD-1) protein is not overexpressed in fetal Down syndrome. 11771762 2001
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 GeneticVariation group BEFREE Glutathione S-Transferase M1 and T1 polymorphisms and hypertension risk: an updated meta-analysis. 30420646 2019
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 GeneticVariation group BEFREE Some studies have recently focused on the association between glutathione S-transferase M1 (GSTM1) and glutathione S-transferase T1 (GSTT1) null polymorphisms and hypertension; however, results have been inconsistent. 25742618 2015
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 GeneticVariation group BEFREE Glutathione-S-transferase M1 and T1 null genotypes are associated with hypertension risk: a systematic review and meta-analysis of 12 studies. 24788870 2014
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 GeneticVariation group BEFREE Glutathione S-transferase M1 and T1 gene polymorphisms and risk of hypertension in tea garden workers of North-East India. 21728793 2011
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 Biomarker group RGD In parallel, Western blotting and RT-PCR showed a similar reduction of GSTM2 in left ventricles and aortas of 4-, 8-, and 16-week-old SHR, which is before the onset of hypertension. 18008142 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 GeneticVariation group BEFREE We then genotyped 753 trios from the Medical Research Council British Genetics of Hypertension Study transmission disequilibrium test cohort for 10 single nucleotide polymorphisms and the GSTM1 deletion and examined renal GSTM expression in a cohort of 27 hypertensive and 18 normotensive subjects. 18551009 2008
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.250 Biomarker group RGD Microarray analysis of rat chromosome 2 congenic strains. 12624007 2003
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE Interaction between glutathione S-transferase M1-null/present polymorphism and adjuvant chemotherapy influences the survival of breast cancer. 30032483 2018
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease GWASCAT Association analysis identifies 65 new breast cancer risk loci. 29059683 2017
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE Glutathione S-transferase M1, T1, and P1 genotypes and breast cancer risk: a study in a Portuguese population. 21559761 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE Glutathione S-transferase M1 and T1 polymorphism and response to neoadjuvant chemotherapy (CAF) in breast cancer patients. 21431478 2011
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE Glutathione S-transferase M1 polymorphism and breast cancer susceptibility: a meta-analysis involving 46,281 subjects. 19936916 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE In conclusion, SNPs/haplotypes in the GSTM3 gene within the GSTMs gene cluster are likely to contribute to breast cancer risk when the GSTM1 is absent. 19856098 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE We genotyped GSTA2_448_C > G (rs2180314), GSTA2_742_A > C (rs6577), GSTM2_-832_T > C (rs638820), GSTO1_-1242_G > A (rs2164624), GSTO1_419_A > C (rs4925), GSTO2_-183_A > G (rs2297235), GSTO2_342_A > G (rs156697), GSTZ1_-4378_A > G (rs1046428), and GSTZ1_94_G > A (rs3177427) by MALDI-TOF MS in the German GENICA breast cancer case-control collection of 1021 cases and 1015 controls and performed breast cancer risk association in general and with respect to the stratifications: menopausal status, family history of breast or ovarian cancer, use of oral contraceptives, use of hormone therapy, body mass index, and smoking as well as histopathological tumor characteristics including hormone receptor status, grade, histology, and node status. 19859803 2010
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE Glutathione S-transferase M1 and P1 polymorphisms and risk of breast cancer and fibrocystic breast conditions in Chinese women. 17624589 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers. 18542066 2008
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE Interaction of genetic polymorphisms in cytochrome P450 2E1 and glutathione S-transferase M1 to breast cancer in Taiwanese woman without smoking and drinking habits. 16758119 2006
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 Biomarker disease BEFREE Glutathione S-transferase M1 status and breast cancer risk: a meta-analysis. 15344211 2004
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma 		0.200 GeneticVariation disease BEFREE Association of homozygous wild-type glutathione S-transferase M1 genotype with increased breast cancer risk. 14973116 2004