Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There appears to be evidence for interaction between amount of smoking, the GSTP1 exon 5 polymorphism, and risk of lung cancer in whites.
|
19240225 |
2009 |
Carcinoma of lung
|
0.100 |
PosttranslationalModification
|
disease |
BEFREE |
The presence of glutathione S-transferase (GST) pi1 (GSTP1) or multidrug resistance gene 1 (MDR1) promoter methylation in lung cancer was studied for the first time to the authors' knowledge; and, to date, the clinical significance of methylation is not clear.
|
19484794 |
2009 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, only four of the previously reported associations with polymorphisms in the GSTP1 (Ala14Val), SOD2 (Val16Ala), EPHX1 (His139Arg) genes and the NAT1 fast acetylator phenotype remained significantly associated with lung cancer.
|
18258609 |
2008 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of our study was to measure the frequency of GSTM1, GSTT1, GSTP1*B and p53 gene polymorphisms in a Brazilian population and determine the possible contribution of these genetic variations to LC risk.
|
18280004 |
2008 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTT1 null genotype was also associated with an increased lung cancer risk (OR, 1.49; 95% CI, 1.17-1.89; p=0.001), but no association was observed for the GSTP1 105Val allele.
|
17428724 |
2008 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The study has been extended to investigate the potential role of polymorphism in GSTP1 alone or in combination with the status of GSTM1 and GSTT1 genes in the likelihood of development of lung cancer.
|
18415801 |
2008 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The polymorphisms of GSTP1 Ile105Val and MPO G-463A showed no significant association with lung cancer.
|
17980933 |
2008 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Interactions between GSTM1, GSTT1 and GSTP1 polymorphisms and smoking and intake of fruit and vegetables in relation to lung cancer.
|
17123660 |
2007 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
After combination study of the three gene-polymorphism, the subjects who were most different with the reference, i.e. had the mutant allele of the GSTP1 and CYP1A1 and homozygous wild type of the MPO, showed approximately 5-fold-higher risk for lung cancer than the reference (95% CI, 2.05-12.05).
|
17428572 |
2007 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTP1 GG genotype was not associated with an overall increased risk of lung cancer (adjusted odds ratio, 1.02; 95% confidence interval [95% CI], 0.78-1.34) compared with the GSTP1 AA genotype.
|
16933328 |
2006 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk of lung cancer is not strongly associated with the I105V and A114V polymorphisms in the GSTP1 gene or with GSTM3 intron 6 polymorphism.
|
16509765 |
2006 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, individuals possessing combined genotypes of N-acetyltransferase 2 (NAT2) rapid acetylator, GSTP1 mutant and both GSTT1(-) and GSTM1(-) have a remarkably higher lung cancer risk than those carrying combined NAT2 slow acetylator genotype, GSTP1 wild genotype and both GSTT1(+) and GSTM1(+) genotypes.
|
16788248 |
2006 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Individuals in this high ETS exposure category carrying the GSTM1 null and the GSTP1 Val allele were at over 4-fold increased risk of developing lung cancer (OR = 4.56, 95% CI: 1.21-17.21).
|
15528218 |
2005 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The interaction between GSTP1 105Val mutation and smoking in the development of lung cancer were not detected, nor was hOGG1 326Cys mutation.
|
15896461 |
2005 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No significant single gene associations between GSTM1, GSTT1 or GSTP1 and early-onset lung cancer were identified in Caucasians, after adjusting for age, sex, pack years and family history of lung cancer.
|
15661806 |
2005 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 null genotype, combined GSTT1 and GSTM1 null genotype and GSTP1 Val105/Val105 genotype did not confer any increase risk for lung cancer.
|
15246186 |
2004 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results showed a 2.4-fold (CI = 1.31-4.41) increased risk of lung cancer in GSTT1 null-genotype carriers but no significant effects of the polymorphisms in GSTM1, GSTM3, GSTP1-105 or GSTP1-114.
|
15069685 |
2004 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the current German study we investigated the role of GSTM1, GSTT1 and GSTP1 polymorphisms as a genetic modifier of risk for individuals with lung cancer as susceptible genotypes especially in relation to tobacco smoking.
|
15105047 |
2004 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The effect of the GSTP1 polymorphisms on lung cancer risk was evaluated by considering the joint effect of having both an ETS exposure and the GSTP1 GG genotype compared to the absence of ETS exposure and the GSTP1 AA genotype as a reference group as well as doing stratified analysis by genotype.
|
12640684 |
2003 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent investigations have shown that the GSTM1-null genotype combined with CYP1A1, NAT2, or GSTP1 polymorphisms confers a greater risk of lung cancer than the GSTM1-null genotype alone.
|
12894585 |
2003 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Utilizing a hospital-based case-control study, we investigated the association between GSTP1 polymorphisms at exons 5 and 6 with lung cancer risk.
|
12660004 |
2003 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTT1 was not associated with lung cancer risk and GSTP1 val was non-significantly associated with a modest reduction in risk, particularly among heavy smokers.
|
12781423 |
2003 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTP1 GG genotype approximately doubled the lung cancer risk associated with pack-years.
|
14501269 |
2003 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed the association of three genetic polymorphisms, NAD(P)H quinone oxidoreductase (NQO1), Glutathione-S-transferase P1 (GSTP1), and manganese superoxide dismutase (MnSOD), with lung cancer risk in 198 cases and 332 controls in Taiwan.
|
12711112 |
2003 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The estimated lung cancer risk for GSTM1 null, GSTP1 Ile/Val and GSTP1 Val/Val combined genotype was 1.44 (95% CI: 0.73-2.83), suggesting the absence of modifying effect of defective GSTM1 and GSTP1 alleles on lung cancer predisposition.
|
14628089 |
2003 |