Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The Relation between Polymorphisms in Exon 5 and Exon 6 of GSTP1 Gene and the Risk of Lung Cancer in Iranian People
|
31127915 |
2019 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study.
|
29556330 |
2018 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTP1 G allele/GG genotype is associated with the lung cancer susceptibility.
|
30539850 |
2018 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTP1 Ile105Val was associated with increased lung function, reduced risk for lung cancer and tobacco-related cancer, and reduced all-cause mortality in the general population.
|
28739440 |
2017 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
To investigate the value of Ubiquitin specific peptidase 8 (USP8), Chitinase 3-like 1 (YKL40), Heat shock protein 90a (HSP90α), glutathione S-transferase P1 (GSTP1), carcinoembryonic antigen (CEA), neuron specific enolase (NSE) and cytokeratin fragment antiogen 21-1 (CYFRA21-1) in bronchoalveolar lavage fluid (BALF) and serum for diagnosis in patients with peripheral lung cancer.
|
26260621 |
2017 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriers of rs4646903 in CYP1A1, rs1048943 in CYP1A1, rs1695 in GSTP1, rs13181 in ERCC2, and rs25487 in XRCC1 are more likely to develop lung cancer.
|
27819744 |
2016 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests that GSTP1 Ile105Val polymorphism may increase the risk of lung cancer in the Chinese population.
|
26458582 |
2016 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The results indicate that the GSTP1 341C/T polymorphism may contribute to lung cancer risk.
|
27525882 |
2016 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There is a twofold increased risk for lung cancer with the null GSTM1 and wild-type GSTP1 genotypes (P=0.0004); similarly, a fourfold increased risk was observed with the null GSTT1 and wild-type GSTP1 genotypes (P=0.0001).
|
26529288 |
2015 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
When Phase 2 software was used to reconstruct the haplotype for GSTP1, the haplotype CACA (rs749174+rs1695 + rs762803+rs4891) exhibited an increased risk of lung cancer among smokers (adjust odds ratio 1.53; 95%CI 1.04-2.25, P=0.033).
|
24786234 |
2014 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
The ATP-binding cassette transporter gene ABCB1 and the glutathione S-transferase gene GSTP1 code for a multidrug resistance protein and for a detoxifying phase II metabolic enzyme, respectively, with substrate specificities that include chemotherapy drugs often used to treat lung cancer.
|
25122423 |
2014 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To study the relationship of susceptibility to lung cancer with the gene polymorphisms of CYP1A1, GSTM1, GSTM3, GSTT1, GSTP1 and smoking status in Han and Mongolian populations of Inner Mongolia, an autonomous region of China.
|
25040976 |
2014 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, there is no evidence showing a significant correlation between GSTP1 Ile105Val gene polymorphism and lung cancer risk in overall population, however stratified analysis by ethnicity, histology, gender and smoking status, it correlate with increased lung cancer susceptibility among Asians and smokers.
|
24566690 |
2014 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
FHIT methylation may play a role in lung cancer later metastatic stages while GSTP1 methylation may rather play a role in the early pathogenesis.
|
24935385 |
2014 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Seventeen reports were included into this meta-analysis for the association of GSTP1 A/G gene polymorphism and histological types of lung cancer.
|
23184053 |
2013 |
Carcinoma of lung
|
0.100 |
Biomarker
|
disease |
BEFREE |
GSTP1 G allele or GG genotype is not a biomarker to be associated with the susceptibility of adenocarcinomas of lung cancer.
|
23736019 |
2013 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggested that there might be an association between GSTP1 Ile105Val polymorphism and lung cancer in the Chinese Han population.
|
22797821 |
2012 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
CYP1A1 rs4646903 (OR = 1.72, 95% CI = 1.25-2.38), rs1048943 (OR = 1.40, 95% CI = 1.02-1.92), the GSTM1 deletion polymorphism (OR = 1.38, 95% CI = 1.01-1.89), GSTP1 rs1695 (OR =1.48, 95% CI = 1.04-2.11), ERCC2 rs13181 (OR = 1.89, 95% CI = 1.28-2.78), and Chinese hamster 1 rs25487 (OR = 1.54, 95% CI = 1.12-2.13) were associated with lung cancer risk whereas the GSTT1 deletion polymorphism and XRCC3 rs861539 were not.
|
22525558 |
2012 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated if the individual and/or combined modifying effects of the CYP1A1 MspI T6235C, GSTM1 present/null, GSTT1 present/null and GSTP1 Ile105Val polymorphisms are related to the risk of developing lung cancer in relation to tobacco consumption and occupation in Asturias, Northern Spain.
|
23013535 |
2012 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These results show that GSTP1 exon 6 polymorphism might be an important factor in determining lung cancer susceptibility in a Turkish population.
|
22207177 |
2012 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, GSTP1 G allele is associated with the lung cancer susceptibility.
|
23065248 |
2012 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
No overall association between lung cancer and GSTT1 null or GSTP1 Ile105Val was found.
|
20729793 |
2010 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Haplotype-tagging SNPs were selected and GSTP1 haplotypes were tested for genetic association to lung cancer using unconditional logistic regression after adjusting for confounders.
|
19282111 |
2009 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Lung cancer risk associated with individual SNPs was seen for GSTP1 [A allele; odds ratio (OR) = 1.85; 95% confidence interval (CI), 1.04-3.27] and XRCC1 (A/A genotype; OR = 1.68; 95% CI, 1.01-2.79) in white women and CYP1B1 (G allele; OR = 11.1; 95% CI, 1.18-104) in black women smokers.
|
19174490 |
2009 |
Carcinoma of lung
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was a marginally significant association between LC and GSTT1 null genotype (OR = 1.3; 95% CI: 1.0-1.7) while no significant risk association was found between GSTP1 polymorphism and LC.
|
19009239 |
2009 |