|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Carriers of GSTM1/T1 null and GSTP1 val genotypes were more susceptible to indoor air pollution exposures, having a higher risk of asthma and lung function deficits.
|
29557517 |
2018 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Comparing to controls, significant association with asthma was observed for GSTP1 rs1695 AA genotype (odds ratio (OR) - 1.96; 95% CI - 1.18 to 3.25; p=0.010).
|
27561723 |
2018 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
CTD_human |
In children with high BPAG, the GSTP1 AA genotype was related to a higher odds of asthma than the GG genotype (aOR, 4.84; 95% CI, 1.0223.06).
|
29411558 |
2018 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In children with high BPAG, the GSTP1 AA genotype was related to a higher odds of asthma than the GG genotype (aOR, 4.84; 95% CI, 1.0223.06).
|
29411558 |
2018 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In this study we determined the relationship between the ADRB2 Arg16Gly polymorphism and GSTP1 polymorphisms, involved in bronchodilator response and oxidative stress, respectively, with susceptibility to asthma.
|
27385593 |
2016 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether the GSTT1, GSTM1 and GSTP1 gene polymorphisms modified the associations between TRAP exposure during the first year of life and asthma, wheeze and hay fever in adolescence.
|
27043549 |
2016 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Children with AA at nucleotide 1695 in GSTP1 who had been exposed to ETS and a low vitamin A intake have an increased risk of asthma diagnosis (aOR, 4.44; 95 % CI,1.58-12.52) compared with children who had not been exposed to the two risk factors.
|
26490046 |
2015 |
|
Asthma
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Three of these genes were previously implicated in both asthma and IBD (ZPBP2 IL1R1, and IL18R1) and 3 in asthma only (PYHIN1, IL2RB, and GSTP1).
|
25895113 |
2015 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
In relation to air pollution exposure, children with one or more GSTP1 rs1138272 minor allele were at increased risk of current asthma [odds ratio (OR) = 2.59; 95% CI: 1.43, 4.68 per 10 μg/m3 NO2] and ever asthma (OR = 1.64; 95% CI: 1.06, 2.53) compared with homozygous major allele carriers (OR = 0.95; 95% CI: 0.68, 1.32 for current and OR = 1.20; 95% CI: 0.98, 1.48 for ever asthma; Bonferroni-corrected interaction p = 0.04 and 0.01, respectively).
|
24465030 |
2014 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Gene polymorphisms in NAT2 (rs4271002), Nrf2 (rd6726395), and GSTP1 (rd1695) increased the risk of treatment for asthma within the last 12 months.
|
23622008 |
2013 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The meta-analysis of the GSTM1 (n = 35), GSTT1 (n = 31) and GSTP1 (n = 28) studies suggests that no significant associations with asthma susceptibility were observed for GSTM1 and GSTP1 gene polymorphisms, whereas a significant outcome was detected for the GSTT1 positive/null genotype (pooled OR = 1.33, 95 %CI = 1.10-1.60).
|
23307299 |
2013 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
GSTP and GSTA are thought to play an important role in protecting the airways of asthmatics compared with GSTM and GSTT.
|
23647087 |
2013 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
To assess the joint effect of air pollutants and GSTP1 on asthma/wheezing, we conducted a nationwide cross-sectional study of 3,825 children in Taiwan Children Health Study.
|
23357926 |
2013 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether GSTM1, GSTT1, and GSTP1 polymorphisms are associated with asthma development.
|
22812193 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
To assess the effect of IL13 (-1112 C>T and Arg110Gln), GSTP1 (Ile105Val), and CYP1A1 (Ile462Val) on asthma risk and ETS exposure, we recruited 201 unrelated children and classified them into four groups: (1) control without ETS exposure; (2) control with ETS exposure; (3) with asthma and with ETS exposure and (4) with asthma and without ETS exposure.
|
22236719 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
The aim of the present study was to investigate the role of polymorphisms in the GSTT1, GSTM1 and GSTP1 genes and asthma susceptibility in Egyptian children, and to analyze their effect on GST activity and lung function.
|
22326267 |
2012 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The results of this study suggest that GSTP1, INSIG2 and IL4Ra may influence the lifetime asthma susceptibility through gene-gene interactions in schoolchildren.
|
22355322 |
2012 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Chromosome 11 haplotype CTACGAGGCC (corresponding to MS4A2 rs574700, rs1441586, rs556917, rs502581, rs502419 and GSTP1 rs6591256, rs17593068, rs1695, rs1871042, rs947895) was associated with a nearly five-fold increase in the odds of asthma (Odds Ratio (OR) = 4.8, p = 0.007).
|
21320344 |
2011 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to analyze if some functional polymorphisms of GSTA1, GSTM1, GSTP1, GSTO2 and GSTT1 are associated with asthma in pediatric patients from Chieti (Italy).
|
22040239 |
2011 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Associations between ETS exposure, GSTP1 polymorphisms, and their interaction on atopy and asthma severity were investigated.
|
20858151 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether common, functional polymorphisms in GSTM1, GSTP1 and NQO1 influence airway hyperreactivity (AHR) and atopy among schoolchildren in South Africa.
|
20526719 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Meta-analysis of GSTP1 Ile105Val (n = 17) and asthma suggested a possible protective effect of the Val allele, but heterogeneity was extreme.
|
20032267 |
2010 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 null was independently associated with an increased risk of asthma and showed little variation with air pollution or GSTP1 genotype.
|
18988661 |
2009 |
|
Asthma
|
0.400 |
GeneticVariation
|
disease |
LHGDN |
GSTM1 null was independently associated with an increased risk of asthma and showed little variation with air pollution or GSTP1 genotype.
|
18988661 |
2009 |
|
Asthma
|
0.400 |
Biomarker
|
disease |
CTD_human |
GSTM1 null was independently associated with an increased risk of asthma and showed little variation with air pollution or GSTP1 genotype.
|
18988661 |
2009 |