|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Proliferation and apoptosis assays regarding GSTP1 expression were examined in ESCC cell lines.
|
30499150 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Highly expressed LINC01419 in ESCC promotes GSTP1 methylation, which ultimately acts to promote the event of ESCC and diminish the sensitivity of ESCC cells to 5-FU, highlighting a novel potential strategy to improve 5-FU-based chemotherapy in ESCC.
|
31019568 |
2019 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Reduced expression of GSTP1 in PBMCs was significantly associated with the risk for ESCC, suggesting an important etiology clue to the early progression of ESCC in the Huaian population of China.
|
22853296 |
2012 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neither the GSTT1 deletion nor the GSTP1 Ile105Val polymorphism was associated with OSCC risk in the Black or Mixed Ancestry populations.
|
22216261 |
2011 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Smoking along with GSTP1 Val/Val genotype was associated to ESCC (p<0.001, OR: 3.886, 95% CI=1.830-8.251), while non-smokers with GSTP1 Val/Val were significantly more frequent in non-cancerous group.
|
20409775 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GSTP1 protein levels also showed significant decrease in ESCC when adjusted for age, gender, smoking status, and alcohol use.
|
20391126 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The risk for OSCC in the combined GSTP1 341C/T and T/T genotypes was higher in tobacco smokers (OR = 7.51, 95% CI 3.82-14.7), alcohol consumers (OR = 15.3, 95% CI 1.81-12.9) and those using wood or charcoal for cooking and heating (OR = 12.1, 95% CI 3.26-49) when compared to those who did not smoke tobacco, or did not consume alcohol or user other forms of fuel for cooking and heating.
|
20540773 |
2010 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Finally, we performed a meta-analysis and found that GSTP1 polymorphism seems to be associated with the risk of esophageal squamous cell carcinoma among Caucasian population (OR = 1.4; 95% CI 1.0-2.2; p value for heterogeneity test 0.34).
|
19618282 |
2009 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, this study suggests an opposite role of GSTP1 and GSTT1 polymorphisms for the risk for ESCC.
|
17916905 |
2007 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We studied the joint effects of dietary selenium and the GSTP1 and p53 polymorphisms on ESCC risk in a population-based case-control study with 218 ESCC cases and 415 controls in Taixing City, China.
|
16492918 |
2006 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
To determine if genetic polymorphisms of CYP1A1, GSTM1, GSTP1, or GSTT1 are associated with an increased risk of developing esophageal squamous cell carcinoma (ESCC), gastric cardia cancer (GCC), or either in a high-risk Asian population.
|
15801491 |
2004 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We present a hospital-based case-control study, which included 90 patients of esophageal squamous-cell carcinoma (ESCC) and 254 healthy people in Taiwan, to investigate the effects of genetic polymorphisms of p53, GSTP1 and NAT2 on the risk of ESCC.
|
11008209 |
2000 |
|
Squamous cell carcinoma of esophagus
|
0.100 |
Biomarker
|
disease |
BEFREE |
Polymorphisms of GSTP1 and NAT2 may serve as genetic biomarkers for predicting susceptibility to esophageal squamous-cell carcinoma.
|
9761122 |
1998 |