Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
The progressive loss of GSTP1 expression from healthy glands to PIN and to PCa glands underlines its involvement in early carcinogenesis.
|
27594734 |
2016 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
Biomarker
|
disease |
CTD_human |
Dietary carcinogen 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine-induced prostate carcinogenesis in CYP1A-humanized mice.
|
22581815 |
2012 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
GeneticVariation
|
disease |
BEFREE |
Significantly increased methylation levels in cancer specimens were found for all promoter regions (GSTP1: 21/25, 84%; RARβ2: 24/25, 96%; APC: 21/25, 84%; PITX2: 20/25, 80%) and in most samples containing prostatic intraepithelial neoplasia.
|
21116117 |
2010 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
The silencing of GSTP1 results from aberrant methylation at the CpG island in the promoter-5' and occurs in the vast majority of cases of high-grade prostatic intraepithelial neoplasia (PIN) and prostate cancers.
|
17558856 |
2007 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
When analyses have been carefully conducted, GSTP1 CpG island hypermethylation has not been found in DNA from normal prostate tissues, or from benign prostatic hyperplasia (BPH) tissues, though GSTP1 CpG island hypermethylation changes have been detected in DNA from candidate prostate cancer precursor lesions proliferative inflammatory atrophy (PIA) and prostatic intraepithelial neoplasia (PIN).
|
14755684 |
2004 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
However, aberrant methylation of the CpG island of the GSTP1 gene promoter silences GSTP1 gene expression and protein levels, setting the stage for additional genetic damage and accelerated progression toward PIN and carcinoma.
|
14607218 |
2003 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
BEFREE |
Glutathione S-transferase P1 (GSTP1) is markedly downregulated in prostate cancer and prostatic intraepithelial neoplasia compared to normal prostate tissue.
|
15195126 |
2002 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
PosttranslationalModification
|
disease |
BEFREE |
In adenocarcinoma, a strong association (P < 0.00001) between GSTP1 promoter hypermethylation and loss of GSTpi expression was observed; however, this trend was not retained in prostatic intraepithelial neoplasia or BPH lesions.
|
12010858 |
2002 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
AlteredExpression
|
disease |
LHGDN |
GSTA1 expression in normal, preneoplastic, and neoplastic human prostate tissue.
|
11550208 |
2001 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
Biomarker
|
disease |
BEFREE |
Loss of GSTP1 function also appears to be characteristic of prostatic epithelial neoplasia (PIN) lesions, thought to represent PCA precursors.
|
11795433 |
2001 |
Prostatic Intraepithelial Neoplasias
|
0.400 |
Biomarker
|
disease |
BEFREE |
Hypermethylation of the 5'-regulatory region of the GSTP1 gene may serve as an important molecular genetic biomarker for both prostate cancer and PIN.
|
9641498 |
1998 |