Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Male null carriers for both GSTT1 and GSTM1 were approximately three times more at risk of developing cancer at an earlier age when compared to non-null males.
|
17087981 |
2006 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The gene GSTT1 has a null/present polymorphism in one of the targets for cancer susceptibility research.
|
17140374 |
2006 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The frequencies of homozygous GSTM1 null and GSTT1 null genotypes were found to be significantly higher in cancer patients as compared with healthy controls (P = .009, odds ratio [OR] 1.52, 95% confidence interval [CI], 1.1 to 2.0 and P = .0004, OR 2.4, 95% CI: 1.4 to 4.0, respectively).
|
18177825 |
2008 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Inheritance of the GSTT1 null genotype conferred a twofold risk of cancer that was statistically significant with crude data (OR 2.18; 95% CI 1.38-3.43), but not after adjustment for age (OR 1.91; 95% CI 0.99-3.70).
|
11422615 |
2001 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
GSTM1 and GSTT1 showed deletion polymorphisms and heterozygous deletion confers protection against cancer.
|
24452716 |
2014 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
While the genetic polymorphisms GSTM1 and GSTT1 have drawn particular interest in relation to cancer susceptibility, previous studies of colorectal cancer are inconsistent regarding their role.
|
11165755 |
2001 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
We analyzed germline polymorphisms in genes that have been associated with cancer susceptibility and whose products activate (cytochrome P450 1A1 [CYP1A1]) and detoxify (glutathione S-transferases M1 [GSTM1] and T1 [GSTT1]) chemical carcinogens found in tobacco smoke.
|
10580025 |
1999 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
GSTM1 and GSTT1 are polymorphic genes.Absence of enzyme activity is due to homozygous inherited deletion of the gene, reducing detoxification of carcinogens such as epoxides and alkylating agents and potentially increasing cancer risk.
|
10868689 |
2000 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The homozygous deletions or null genotypes of GSTT1 (theta class) and GSTM1 (mu class) genes may be associated with an increased risk of cancer.
|
10667466 |
2000 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The frequency of homozygous GSTT1 null genotype in cancer cases was 19.7% in comparison to 12.5% in controls, however, the difference was not statistically significant (OR=1.7, 95% CI: 0.8-3.8).
|
15004652 |
2004 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A Bayesian analysis of the influence of GSTT1 polymorphism on the cancer risk estimate for dichloromethane.
|
11446825 |
2001 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The GSTM1 and GSTT1 isoenzymes exhibit deletion polymorphisms, resulting in a lack of activity, and the null genotypes have been associated with increased cancer risk at several sites, including the stomach, although with contrasting results.
|
15688399 |
2005 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the current study, allelic polymorphisms of GSTM1 and GSTT1 were analyzed in three ethnic groups of North East (NE) India where a high prevalence of various cancers and other diseases such as hypertension, tuberculosis, and asthma have been reported.
|
20073549 |
2010 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
The wild-type (i.e., functional) genotype of GSTT1, which is associated with lower cancer risk, might be associated with exceptional longevity, yet further studies with larger sample sizes must confirm these findings.
|
21894447 |
2012 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Significant differences between control and cancer cases were observed for GSTT1 null genotypes both in <=50 yrs and >50 yrs of age groups (OR=4.0; 95%CI=1.1-15.0; p=0.03) (OR=4.5; 95%CI=0.97-22.29; p=0.05), respectively.
|
16830058 |
2006 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
GSTM1, GSTT1 and GSTP1 genotype frequencies were determined in bladder cancer cases (n=72) and healthy controls with no history of malignancies (n=82) using PCR-based techniques.
|
15832776 |
2005 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
A deletion polymorphism of the gene encoding the cytosolic detoxification enzyme glutathione S-transferase theta 1 (GSTT1) has been extensively studied for cancer susceptibility (919 studies, from HuGE navigator, http://www.HuGEnavigator.net/).
|
19424424 |
2009 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Moreover, a logistic regression analysis of possible predictors for myeloid malignancies, controlling for gender and race, did not reveal an association of GSTM1 or GSTT1 null genotypes (P = 0.62 and 0.11, respectively) with treatment-related malignancies.
|
10673738 |
2000 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
In the present case-control study, we aimed at estimation of the relationship between the GSTM1, GSTT1, and GSTP1 genotypes and the susceptibility to various types of childhood malignancies and the early relapses of diseases.
|
15382272 |
2004 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Review confirms the data of previous reviews that GSTM1 and GSTT1 gene polymorphisms may be risk factors for cancer initiation.
|
23886141 |
2013 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Inter-individual variations in GSTM1 and GSTT1 loci have been associated with several types of cancer, including leukemias.
|
21969307 |
2012 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Effects of glutathione S-transferase (GST) M1 and GSTT1 genotypes on urothelial cancer risk.
|
10397466 |
1998 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
To evaluate the influence of GST profile in different age and gender groups regarding the risk of developing cancer and its relationship to smoking habit, the GSTT1, GSTM1, and GSTP1 genotypes of 785 Brazilian patients with cancer and 873 cancer-free controls paired on the basis of sex, age, ethnicity, diet and exercise routine, lifetime occupational history, smoking history, general health conditions, and previous diseases were compared.
|
19114965 |
2009 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
Heavy tobacco chewing (> 124 chewing-year) increased the risk of cancer in individuals with GSTT1 homozygous null genotype (OR = 3.0; 95% CI = 1.0-9.8).
|
14735473 |
2004 |
Malignant Neoplasms
|
0.400 |
GeneticVariation
|
group |
BEFREE |
PIA identified previously described null polymorphisms in glutathione-S-transferase T1 (GSTT1) as the best predictor of colon cancer among the studied SNPs, and also identified novel polymorphisms in the inflammation and hormone metabolism pathways that singly or jointly predict cancer risk.
|
16217767 |
2006 |