|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTT1 null (but not other genotypes) was associated with a minor increased risk for asthma attack and there were no significant associations between GST genotypes and asthma severity.
|
29785881 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Overall, carriers of the GSTT1 null genotype had an increased risk of asthma and allergic outcomes if exposed to TRAP.
|
27372567 |
2017 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, in GSTT1 null carriers, every 100 m increase in cumulative lengths of major road exposure during the first year of life was associated with a 2.31-fold increased risk of wheeze and a 2.15-fold increased risk of asthma at 12 years.
|
27043549 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Few and contradictory data are available on the association between asthma development and GSTT1 and GSTM1 polymorphisms in different ethnic groups.
|
24559168 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The meta-analysis of the GSTM1 (n = 35), GSTT1 (n = 31) and GSTP1 (n = 28) studies suggests that no significant associations with asthma susceptibility were observed for GSTM1 and GSTP1 gene polymorphisms, whereas a significant outcome was detected for the GSTT1 positive/null genotype (pooled OR = 1.33, 95 %CI = 1.10-1.60).
|
23307299 |
2013 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
GSTP1, GSTM1, and GSTT1 mRNA expressions were not different between asthmatics and healthy controls.
|
23647087 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis provides evidence that GSTM1 and GSTT1 polymorphisms may be risk factors for asthma.
|
23600494 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, there is a significant association between GSTT1 null genotype and risk of asthma during childhood in Caucasians.
|
23076538 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTT1 null allele was more prevalent in asthma patients (40 %) than in the control subjects (13.3 %), which yielded a nearly fourfold risk towards asthma with odds ratio (OR) (95 % CI) = 4.35 (3.04-6.24), χ(2) = 75.34, and p = 0.000.
|
22484660 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate whether GSTM1, GSTT1, and GSTP1 polymorphisms are associated with asthma development.
|
22812193 |
2012 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GSTT1 showed a significant interactive effect with incense burning on current asthma, current wheeze and nocturnal wheeze.
|
21109554 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The aim of the present study is to analyze if some functional polymorphisms of GSTA1, GSTM1, GSTP1, GSTO2 and GSTT1 are associated with asthma in pediatric patients from Chieti (Italy).
|
22040239 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The meta-analyses of GSTM1 (n = 22 studies) and GSTT1 (n = 19) showed increased asthma risk associated with the null genotype, but there was extreme between-study heterogeneity and publication bias and the association disappeared when meta-analysis was restricted to the largest studies.
|
20032267 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Risk of asthma associated with late gestation exposure was higher when maternal GSTT1 genotype was present rather than absent (P interaction, .006), and risk of wheezing was increased when maternal GSTM1 was present (P interaction, .04).
|
21051083 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In the current study, allelic polymorphisms of GSTM1 and GSTT1 were analyzed in three ethnic groups of North East (NE) India where a high prevalence of various cancers and other diseases such as hypertension, tuberculosis, and asthma have been reported.
|
20073549 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We assessed whether polymorphisms of GST genes (GSTM1, GSTT1, and GSTP1) are associated with asthma and atopy among Tunisian children.
|
17497028 |
2007 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A study was undertaken to investigate associations of variants in EPHX1, GSTM1, GSTP1 and GSTT1 with asthma and the relationships between asthma, EPHX1 metabolic phenotypes and exposure to sources of PAHs.
|
17711870 |
2007 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 or GSTT1 polymorphisms had also no relevant developing effect on NP patients without or with asthma.
|
16550944 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of the GSTM1 and GSTT1 genes, both individually and in combination, were not associated with the development of allergic diseases including asthma in the Czech population, the GSTM1 gene variability, however, may influence lung functions in our asthmatics.
|
16409207 |
2006 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated the association of lung function with GSTM1, GSTP1 and GSTT1 genotypes in Caucasian families with asthma.
|
16164441 |
2005 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
GSTT1 was significantly associated in an additive model to asthma, in which the alleles carrying the deletion of the gene were transmitted to affected offspring more often than expected by chance (p=0.019).
|
15300848 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Patients with atopic asthma (34.4%) had a higher prevalence of the GSTT1 null genotype than the nonatopic asthma patients (13.5%; OR = 3.83; 95% CI, 1.24-11.78).
|
15612961 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The same transmission disequilibrium of the null GSTT1 allele was seen in patients with atopic asthma (p=0.021).
|
15300848 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
Combination of CC16, GSTM1, and GSTT1 genetic polymorphisms is associated with asthma.
|
15148962 |
2004 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The association between GSTM1 and GSTT1 genotypes and asthma as well as atopy was investigated with respect to current and in utero ETS exposure.
|
15223862 |
2004 |