Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no association between GSTM1/GSTT1 gene polymorphisms and OCPs in BC patients.
|
31009110 |
2019 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the GSTM1-null, GSTT1-null and dual-null GSTM1-GSTT1 genotypes might be associated with the onset of bladder cancer, but additional genetic-epidemiological studies should be conducted to explore this association further.
|
30419877 |
2018 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent molecular epidemiology has indicated that activation of brominated trihalomethanes by the enzyme GSTT1 and the lack of metabolism of haloacetic acids by a variant of enzyme GSTZ1 are likely causative mechanisms for bladder cancer associated with exposure to chlorinated water.
|
29875071 |
2018 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC.
|
28403014 |
2018 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, no significant association between GSTT1 polymorphism and bladder cancer was found.
|
30539835 |
2018 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Stratified analyses of population-based associations indicated increased bladder cancer risk associated with GSTM1-null and GSTM1/GSTT1 double-null genotypes in hospital-based and population-based studies.
|
27911277 |
2017 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The phase II enzymes N-acetyltransferase 2 (NAT2), glutathione S-transferases M1 (GSTM1), and T1 (GSTT1) and the single nucleotide polymorphism (SNP) rs11892031[A/C] reported to be associated with bladder cancer in genome-wide association studies were genotyped.
|
28696895 |
2017 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
GSTT1 exerted no marked influence on bladder cancer (negative 21% cases vs. 22% controls).
|
28696897 |
2017 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, common polymorphisms in GSTA1, GSTM1 and GSTT1 are associated with susceptibility to BC in individuals from BEN areas of Serbia.
|
27568660 |
2016 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study suggested that GSTM1 null genotype and GSTT1 null genotype might be related to higher BCa risk, respectively.
|
27631264 |
2016 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no association between bladder cancer and GSTM1 polymorphism (ORs = 0.64, 95% CI = 0.32-1.29), but the probability of bladder cancer in patients with GSTT1 null genotype (67.9%), was significantly higher from the probability of bladder cancer with GSTT1 normal genotype (43.0%) statistically (ORs = 2.8, 95% CI = 1.16-6.75).
|
25284638 |
2015 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined association between GSTA1, GSTM1, GSTP1, and GSTT1 gene variants and bladder cancer risk and evaluated whether they were modified by smoking.
|
24075358 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was a significant multiple interaction between GSTM1, GSTT1, and GSTP1 genotypes in risk of bladder cancer (P for interaction = 0.02).
|
22154357 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that inherited absence of GSTT1 gene may be associated with bladder cancer susceptibility, and specific combinations of GSTM1, GSTT1 and CYP1B1 gene polymorphisms may modify bladder cancer risk in the Turkish population, without any association being observed for CYP1A1 gene polymorphism and bladder cancer risk.
|
23886208 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combination of the high-risk genotypes (GSTM1 null + GSTT1 null + GSTP1 313 A/G or G/G) demonstrated further increase in the BC risk (OR = 6.64, 95 %CI = 3.63-12.16).
|
23054023 |
2013 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Besides, smoking was not found to modify the association between the GSTT1 null genotype and BC risk.
|
22339266 |
2012 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects with the GSTT1-null genotype might be at an increased risk of bladder cancer in Canary Islands, Spain.
|
21292509 |
2012 |
Bladder Neoplasm
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To estimate the prevalence and importance of GSTT1 and GSTM1 genotypes (implicated in glutathione S-transferase activity) in bladder cancer, to determine whether smoking and occupational factors influence this relationship, and to identify the value of GSTT1 and GSTM1 genotypes as prognostic factors.
|
20942828 |
2011 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) genotypes using genomic DNA from primary 165 BC tissue samples to assess the association with disease prognosis.
|
21286014 |
2011 |
Bladder Neoplasm
|
0.100 |
Biomarker
|
disease |
BEFREE |
GSTT1 may play an important role in tumorigenesis and disease progression in patients with BC.
|
21079384 |
2011 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that common genetic variations in GSTM1, GSTT1, and GPX1 were not associated with bladder cancer risk.
|
21586620 |
2011 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations between THMs and bladder cancer were stronger among subjects who were GSTT1 +/+ or +/- versus GSTT1 null (P(interaction) = 0.021), GSTZ1 rs1046428 CT/TT versus CC (P(interaction) = 0.018), or CYP2E1 rs2031920 CC versus CT/TT (P(interaction) = 0.035).
|
20675267 |
2010 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is suggested that NAT2 slow-acetylator, GSTM1 null, GSTM1/GSTT1-double null, and variant CYP2A6 genotypes may play important roles in the development of bladder cancer in Henan area, China.
|
19303722 |
2009 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, we found that NAT2 slow acetylator individuals temporarily carrying wild-type GSTT1 or GSTM1 null genotypes have a strong increased risk of bladder cancer (OR= 26 and 22.17, respectively).
|
19380028 |
2009 |
Bladder Neoplasm
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These data seem to indicate that GSTT1 gene polymorphism may be associated with BC in the Turkish population studied.
|
18690546 |
2009 |