|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The remaining five of the 28 polymorphisms were not associated with endometriosis: glutathione S-transferase theta 1 (GSTT1) null genotype, vascular endothelial growth factor alpha (VEGFA) rs699947, rs833061, rs2010963 and rs3025039.
|
31821471 |
2020 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, GSTM1, GSTT1, and GSTP1 rs1695 polymorphisms did not affect the pathogenesis of endometriosis.
|
28002584 |
2016 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
The findings suggest that the GSTM1 and GSTT1 gene deficiency predisposes to endometriosis in a Tunisian population and can confer a significant increased risk when the GST null genotypes are combined.
|
25549292 |
2015 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTT1 polymorphism (null genotype) was more prevalent in the endometriosis group than in the control group (OR = 0.53; 95 % CI 0.94-0.29 (p = 0.039).
|
26350109 |
2015 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, our meta-analysis supports that the GSTM1/GSTT1 null genotype might contribute to individual susceptibility to endometriosis in Chinese populations, especially in Chinese Han.
|
26370772 |
2015 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Moreover, we found a significant positive association between the dual null genotype GSTM1-GSTT1 and endometriosis susceptibility (OR = 1.33, 95% CI: 1.03-1.72, P = 0.027).
|
25208225 |
2014 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The contributions of GSTM1 and GSTT1 polymorphisms to the proliferation of endometriosis were not statistically significant, but the analysis of pathology and the association of GSTM1 and GSTT1 gene polymorphisms with p53 codon 72 revealed statistical significance.
|
23979901 |
2013 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Carriage of the GSTT1 null deletion variant showed consistent association with endometriosis with a 29% increased risk; however, it cannot be excluded that this result was due to publication bias, and this association should be independently confirmed in large-scale, well-designed case-control studies.
|
18805939 |
2009 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
These findings suggest that the AhRR codon 185 and GSTT1 polymorphisms are associated with the risk of advanced stage endometriosis.
|
17513317 |
2007 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
These findings suggest that the AhRR codon 185 and GSTT1 polymorphisms are associated with the risk of advanced stage endometriosis.
|
17513317 |
2007 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We observed an association between endometriosis and the GSTM1 null deletion, but not with GSTT1 null deletions or the CYP1A1 MspI polymorphism in South Indian women.
|
15861041 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The objective of the present study was to investigate whether the polymorphisms of GSTM1, GSTT1 and GSTP1 are related to endometriosis.
|
15531593 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Many studies have investigated the role of GSTM1 and GSTT1 gene polymorphisms in endometriosis.
|
15878920 |
2005 |
|
Endometriosis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In view of the controversies surrounding the glutathione S-transferases (GST) M1/T1-endometriosis association, a meta-analysis of the GSTM1/GSTT1 genetic association studies of endometriosis was performed.
|
16291859 |
2005 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
An association was found between GSTT1-null genotype and endometriosis in the Hans, but not in the Uygurs.
|
15059587 |
2004 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTM1 and GSTT1 null genotypes may be risk factors for the development of endometriosis.
|
12875700 |
2003 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
To investigate the possibility of genetic contribution of CYP1A1, CYP19, GSTM1, and GSTT1 polymorphisms to endometriosis.
|
12620480 |
2003 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We aimed to replicate this association of endometriosis in a UK population, and to test for association with the GSTT1 null mutation or the cytochrome P450 (CYP) 1A1 MspI polymorphism.
|
11675474 |
2001 |
|
Endometriosis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The combination of CYP1A1 m1 polymorphism and GSTM1 null deletion is closely associated with penetration of the endometriosis phenotype, whereas GSTT1 null deletion may add to the penetration of this trait.
|
11730751 |
2001 |