|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the overall analysis, no significant association between GSTM1, GSTT1 polymorphisms and oral cancer was found in the Chinese population.
|
30539845 |
2018 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In total, 28 loci, that is, 14q32.33 (AKT1), 5q22.2 (APC), 11q22.3 (ATM), 2q33.1 (CASP8), 11q13.3 (CCND1), 16q22.1 (CDH1), 9p21.3 (CDKN2A), 1q31.1 (COX-2), 7p11.2 (EGFR), 22q13.2 (EP300), 4q35.2 (FAT1), 4q31.3 (FBXW7), 4p16.3 (FGFR3), 1p13.3 (GSTM1-GSTT1), 11q13.2 (GSTP1), 11p15.5 (H-RAS), 3p25.3 (hOGG1), 1q32.1 (IL-10), 4q13.3 (IL-8), 12p12.1 (KRAS), 12q15 (MDM2), 12q13.12 (MLL2), 9q34.3 (NOTCH1), 17p13.1 (p53), 3q26.32 (PIK3CA), 10q23.31 (PTEN), 13q14.2 (RB1), and 5q14.2 (XRCC4), were validated to be associated with oral cancer.
|
29037125 |
2017 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our findings suggest that presence of GSTM1 and/or GSTT1 null genotypes along with variant alleles of CYP1A1 may be the risk alleles for oral cancer susceptibility in Pashtun population.
|
25735346 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The impact of GSTM1/GSTT1 polymorphism for the risk of oral cancer.
|
25595865 |
2015 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The results also suggested significant association between tobacco habits, especially chewing, variant genotypes of CYP1A1, GSTM1 and GSTT1 and oral cancer risk.
|
23444898 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In contrast, in studies in India a significant correlation between GSTM1 null genotype and oral cancer was observed (OR=1.59, 95%CI=1.20-2.11, P=0.001), but not in GSTT1 (OR=1.21, 95% CI = 0.84-1.74, P=0.31).
|
24528041 |
2014 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here, we have investigated the association of tobacco - betel quid chewing, HPV infection, GSTM1-GSTT1 null genotypes, and tumour stages with mitochondrial DNA (mtDNA) content variation in oral cancer patients.
|
23469236 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Here we determined the hot spot mutations in the D-loop region and revealing correlation if any, with clinical parameters, along with analysing the genetic polymorphism of GSTT1 and GSTM1 and its susceptibility towards oral cancer.
|
23265943 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Therefore, the present meta-analysis suggests that the GSTT1 null genotype is a risk allele for oral cancer development in Asian populations, but more studies with large sample and well-matched controls are needed to further confirm the finding from the meta-analysis.
|
23609031 |
2013 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Logistic regression yielding odd ratios resulted in no significant association between dietary ITC intake, GSTM1, GSTT1 or GSTP1 genotypes with oral cancer risk overall.
|
21875259 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphisms in the encoding genes (CYP1A1, GSTM1, GSTT1 and GSTP1) potentially may therefore contribute towards risk association for oral cancer.
|
21545219 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTT1 null genotype may not be associated with oral cancer.
|
21436184 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTT1 null and rs1695 were inversely associated with oral leukoplakia while GSTM1 null, GSTT1 null, rs2031920, rs3813867 (CYP2E1), and rs13181 were associated with OC.
|
21741876 |
2011 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The aim of this study was to estimate the relationship of glutathione S-transferases (GST)P1, GSTA1, GSTM1, and GSTT1 gene polymorphisms to oral cancer risk.
|
19953622 |
2010 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Genetic polymorphisms of GSTM1, GSTT1 and CYP1A1 may not be risk factors for oral cancer in the Jakarta population.
|
19469619 |
2009 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Differences in the GSTM1 and GSTT1 null genotype frequencies were observed between individuals of European origin and African origin, but these genotypes do not seem to influence the risk of oral cancer.
|
17418613 |
2008 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study evaluates the influence of genetic polymorphisms of GSTM1 and GSTT1 gene loci on susceptibility to oral cancer.
|
16830058 |
2006 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Considering that tobacco is the main etiological factor in oral cancer and that oral leukoplakia is the most prevalent potentially malignant lesion, together with the fact that GSTT1 polymorphism increases the risk of oral squamous cell carcinoma, the purpose of this study was to investigate the GSTT1 null polymorphism and the risk of oral leukoplakia in individuals with tobacco smoking habits in a Brazilian population.
|
16475728 |
2006 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The prevalence of GSTT1 deficiency (null) was significantly higher in the group with OSSC patients with oral cancer of the floor of the mouth.
|
15878757 |
2005 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Polymorphism at GSTM1, GSTM3 and GSTT1 gene loci and susceptibility to oral cancer in an Indian population.
|
12016153 |
2002 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study looked at the significance of genetic polymorphisms in CYP1A1, GSTM1 and GSTT1 genes in patients with oral cancer.
|
11564581 |
2001 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There is no association between the GSTT1 null allele and oral cancer risk.
|
11246217 |
2001 |
|
Lip and Oral Cavity Carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This case-control study focused on the interactions between oral cancer risk factors and genetic polymorphisms of cytochrome P-450 (CYP) 2E1 and glutathione S-transferase (GST) M1 and GSTT1.
|
9367063 |
1997 |