Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no association between GSTM1/GSTT1 gene polymorphisms and OCPs in BC patients.
|
31009110 |
2019 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recent molecular epidemiology has indicated that activation of brominated trihalomethanes by the enzyme GSTT1 and the lack of metabolism of haloacetic acids by a variant of enzyme GSTZ1 are likely causative mechanisms for bladder cancer associated with exposure to chlorinated water.
|
29875071 |
2018 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
In conclusion, the GSTM1-null, GSTT1-null and dual-null GSTM1-GSTT1 genotypes might be associated with the onset of bladder cancer, but additional genetic-epidemiological studies should be conducted to explore this association further.
|
30419877 |
2018 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, no significant association between GSTT1 polymorphism and bladder cancer was found.
|
30539835 |
2018 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis indicates a possible association between the variant genotypes of GSTM1, GSTT1, NAT2 and SULT1A1, occupational exposure to aromatic amines or PAHs, and development of BC.
|
28403014 |
2018 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
GSTT1 exerted no marked influence on bladder cancer (negative 21% cases vs. 22% controls).
|
28696897 |
2017 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The phase II enzymes N-acetyltransferase 2 (NAT2), glutathione S-transferases M1 (GSTM1), and T1 (GSTT1) and the single nucleotide polymorphism (SNP) rs11892031[A/C] reported to be associated with bladder cancer in genome-wide association studies were genotyped.
|
28696895 |
2017 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Stratified analyses of population-based associations indicated increased bladder cancer risk associated with GSTM1-null and GSTM1/GSTT1 double-null genotypes in hospital-based and population-based studies.
|
27911277 |
2017 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study suggested that GSTM1 null genotype and GSTT1 null genotype might be related to higher BCa risk, respectively.
|
27631264 |
2016 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, common polymorphisms in GSTA1, GSTM1 and GSTT1 are associated with susceptibility to BC in individuals from BEN areas of Serbia.
|
27568660 |
2016 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was no association between bladder cancer and GSTM1 polymorphism (ORs = 0.64, 95% CI = 0.32-1.29), but the probability of bladder cancer in patients with GSTT1 null genotype (67.9%), was significantly higher from the probability of bladder cancer with GSTT1 normal genotype (43.0%) statistically (ORs = 2.8, 95% CI = 1.16-6.75).
|
25284638 |
2015 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combined GSTT1 null and SOD2 with at least one 16Val allele among never smokers encompass reduced BC risk (OR 0.14, 95 % CI 0.03-0.63; P = 0.01) (P heterogeneity = 0.04).
|
24919441 |
2014 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Combination of the high-risk genotypes (GSTM1 null + GSTT1 null + GSTP1 313 A/G or G/G) demonstrated further increase in the BC risk (OR = 6.64, 95 %CI = 3.63-12.16).
|
23054023 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
There was a significant multiple interaction between GSTM1, GSTT1, and GSTP1 genotypes in risk of bladder cancer (P for interaction = 0.02).
|
22154357 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We examined association between GSTA1, GSTM1, GSTP1, and GSTT1 gene variants and bladder cancer risk and evaluated whether they were modified by smoking.
|
24075358 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study was carried out in UBC subjects (n=50) and healthy control subjects (n=50) with an aim to determine the role of GSTM1 and GSTT1 polymorphism and its implication on the OCP detoxification or bioaccumulation which may increase the risk of UBC in humans.
|
24240585 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that inherited absence of GSTT1 gene may be associated with bladder cancer susceptibility, and specific combinations of GSTM1, GSTT1 and CYP1B1 gene polymorphisms may modify bladder cancer risk in the Turkish population, without any association being observed for CYP1A1 gene polymorphism and bladder cancer risk.
|
23886208 |
2013 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Subjects with the GSTT1-null genotype might be at an increased risk of bladder cancer in Canary Islands, Spain.
|
21292509 |
2012 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Besides, smoking was not found to modify the association between the GSTT1 null genotype and BC risk.
|
22339266 |
2012 |
Carcinoma of bladder
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
To estimate the prevalence and importance of GSTT1 and GSTM1 genotypes (implicated in glutathione S-transferase activity) in bladder cancer, to determine whether smoking and occupational factors influence this relationship, and to identify the value of GSTT1 and GSTM1 genotypes as prognostic factors.
|
20942828 |
2011 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We investigated glutathione S-transferase mu (GSTM1) and glutathione S-transferase theta (GSTT1) genotypes using genomic DNA from primary 165 BC tissue samples to assess the association with disease prognosis.
|
21286014 |
2011 |
Carcinoma of bladder
|
0.100 |
Biomarker
|
disease |
BEFREE |
GSTT1 may play an important role in tumorigenesis and disease progression in patients with BC.
|
21079384 |
2011 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our data indicate that common genetic variations in GSTM1, GSTT1, and GPX1 were not associated with bladder cancer risk.
|
21586620 |
2011 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Associations between THMs and bladder cancer were stronger among subjects who were GSTT1 +/+ or +/- versus GSTT1 null (P(interaction) = 0.021), GSTZ1 rs1046428 CT/TT versus CC (P(interaction) = 0.018), or CYP2E1 rs2031920 CC versus CT/TT (P(interaction) = 0.035).
|
20675267 |
2010 |
Carcinoma of bladder
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
It is suggested that NAT2 slow-acetylator, GSTM1 null, GSTM1/GSTT1-double null, and variant CYP2A6 genotypes may play important roles in the development of bladder cancer in Henan area, China.
|
19303722 |
2009 |