|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The pooled analysis showed that both GSTM1 null genotypes (OR = 1.37, 95% CI = 1.18-1.59) and GSTT1 null genotypes (OR = 1.43, 95% CI = 1.23-1.66) increased the risk of HCC.
|
30976200 |
2019 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Under abnormal conditions the excessive reactive oxygen species generation results in genetic predisposition of various genes (as ADH, ALDH, CYP2E1, GSTT1, GSTP1 and GSTM1) involved in xenobiotic metabolic pathways, associated with susceptibility to different liver related diseases such as fibrosis, cirrhosis and hepatocellular carcinoma.
|
26163595 |
2015 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
We speculate that GSTM1 and GSTT1 genotype variations have their own independent function in HCC development and may mutate independently to cause HCC.
|
24852428 |
2014 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In the pooled analysis, significantly increased HCC risks were found for null genotype of GSTM1 (OR = 1.31, 95% CI = 1.07-1.61, P = 0.010, P heterogeneity < 10(-5)) and GSTT1 (OR = 1.47, 95% CI = 1.25-1.74, P < 10(-5), P heterogeneity < 10(-5)).
|
24399650 |
2014 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In a combined analysis, the summary odds ratio for HCC of the GSTT1 null genotype was 1.43 (95% confidence interval (CI) 1.22–1.68, P < 10(−5)).
|
23959468 |
2014 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Our results indicate that both GSTM1 and GSTT1 null genotypes are associated with an increased HCC risk in Chinese population.
|
23437305 |
2013 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
We therefore performed a meta-analysis to derive a more precise estimation of the association between polymorphisms on GSTM1, GSTT1 and HCC.
|
23185284 |
2012 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTT1 null genotype is associated with HCC susceptibility in Chinese.
|
23167353 |
2012 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Furthermore, null genotype of GSTT1 was associated with HCC susceptibility in Asians.
|
23053942 |
2012 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present meta-analysis suggests that GSTM1/GSTT1 null genotypes are associated with increased risk of HCC in Chinese population.
|
21912475 |
2011 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTT1 and GSTM1 null genotypes do not associate with increased risk of HCC.
|
20672314 |
2010 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This meta-analysis suggests null genotypes of GSTM1 and GSTT1 are both associated with increased HCC risk in Asians, and individuals with the dual null genotype of GSTM1/GSTT1 are particularly susceptible to developing HCC.
|
20561699 |
2010 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
GSTT1 null genotype was associated with 2.23-fold (p < 0.05) increased risk for HCC development as compared to the control group.
|
18816171 |
2008 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The overall results suggest that there may be a small excess risk of HCC in individuals with GSTT1 null and possibly also with GSTM1 null genotypes.
|
18065725 |
2008 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
GSTT1 null genotype was associated with 2.23-fold (p < 0.05) increased risk for HCC development as compared to the control group.
|
18816171 |
2008 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In conclusion, polymorphisms in GSTM1 and GSTT1 genes are not related to the incidence of HCC in a high-risk Spanish population.
|
16314088 |
2006 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Although not statistically significant, an increase in HCC risk was observed among light smokers (1-20 pack-years) carrying GSTT1 null (OR = 1.7, 95% CI 0.6-4.7) and NAT2 slow acetylator (OR = 1.3, 95% CI 0.6-3.0) genotypes.
|
15688397 |
2005 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The GSTM1 and GSTT1 null genotypes are associated with an increased risk of HCC in a special geographic environment.
|
15633230 |
2005 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
ADH3(1-1) and GSTT1 null genotypes did not modify the risk of HCC due to alcohol intake whereas an influence of GSTM1 null genotype for high ethanol consumption was suggested.
|
16132793 |
2005 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
A weak association of the HYL1*2 polymorphism with HCC was observed but did not reach statistical significance.GSTT1 was not associated with HCC.
|
15734960 |
2005 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
LHGDN |
The GSTM1 and GSTT1 null genotypes are associated with an increased risk of HCC in a special geographic environment.
|
15633230 |
2005 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The effect of genetic polymorphisms for glutathione S-transferase ( GST) M1, GSTT1, GSTP1-1( GSTP1), cytochrome P450 2E1 ( CYP2E1) and aldehyde dehydrogenase 2 ( ALDH2) on the risk of hepatocellular carcinoma (HCC) was observed in 78 Japanese patients with HCC and 138 non-cancer hospital controls.
|
12759747 |
2003 |
|
Liver carcinoma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Although the GSTT1 and EPHX1 loci did not appear to be related to HCC in the total population of the human study, a polymorphism in GSTA4 was significantly related to risk in the male subset.
|
12907637 |
2003 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Various combinations of GSTM1 and GSTT1 genotypes differentially modified the association of XRCC1 with HCC (P(interaction) =.005); e.g., for individuals with the GSTT1-null/GSTM1-present genotype, the risk of HCC was greater for those with the Gln/Gln genotype (odds ratio = 8.07, 95% confidence interval = 1.67 to 38.93) than for those with the Arg/Arg genotype.
|
14519756 |
2003 |
|
Liver carcinoma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Univariate analysis showed that GSTT1 polymorphism was not associated with HCC, whereas EPHX 113HH and 139HH genotypes increased the risk of HCC (Odds ratio, 3.10; 95% Confidence interval, 1.18-8.12).
|
11440964 |
2001 |