GSTT1, glutathione S-transferase theta 1, 2952

N. diseases: 541; N. variants: 0
Disease: Childhood Astrocytoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.030 GeneticVariation disease BEFREE The gene defect of GSTT1 has been reported to be associated with an increased risk of myelodysplastic syndromes, astrocytoma and meningioma. 9751255 1998
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.030 GeneticVariation disease BEFREE A case-control study was performed to determine if GSTM3 alone or in combination with GSTM1 or GSTT1 influenced susceptibility to high grade astrocytoma. 8824514 1996
CUI: C4086152
Disease: Childhood Astrocytoma
Childhood Astrocytoma 		0.030 Biomarker disease BEFREE Logistic regression analysis showed GSTT1 null and CYP2D6 poor metabolizer were risk factors in astrocytoma (odds ratio = 2.67 P = 0.0005 and odds ratio = 4.17 P = 0.0043, respectively) and meningioma (odds ratio = 4.52, P = 0.0001 and odds ratio = 4.90, P = 0.0132, respectively) when corrected for the other variables. 7671227 1995