GTF2I, general transcription factor IIi, 2969

N. diseases: 249; N. variants: 14
Disease: Thymoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0040100
Disease: Thymoma
Thymoma 		0.020 GeneticVariation disease BEFREE We identified recurrent somatic mutations in TET2, CYLD, SETD2, TP53, FBXW7, HRAS and RB1, and no mutations in GTF2I, supporting the hypothesis that TC and thymoma are distinguishable by their genetic profiles. 28968686 2017
CUI: C0040100
Disease: Thymoma
Thymoma 		0.020 GeneticVariation disease BEFREE In a series of 274 TETs, we detected the GTF2I mutation in 82% of type A and 74% of type AB thymomas but rarely in the aggressive subtypes, where recurrent mutations of known cancer genes have been identified. 24974848 2014