GTF2I, general transcription factor IIi, 2969

N. diseases: 249; N. variants: 14
Disease: Thymic Carcinoma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0205969
Disease: Thymic Carcinoma
Thymic Carcinoma 		0.020 GeneticVariation disease BEFREE GTF2I mutation was observed in 20 (87.0%) cases of type A thymoma, 70 (78.7%) of type AB thymoma, and the frequency decreased with the degree of histological subtype aggressiveness, with the lowest rate in thymic carcinoma (7.7%). 28676218 2017
CUI: C0205969
Disease: Thymic Carcinoma
Thymic Carcinoma 		0.020 GeneticVariation disease BEFREE We identified recurrent somatic mutations in TET2, CYLD, SETD2, TP53, FBXW7, HRAS and RB1, and no mutations in GTF2I, supporting the hypothesis that TC and thymoma are distinguishable by their genetic profiles. 28968686 2017