GUCA2B, guanylate cyclase activator 2B, 2981

N. diseases: 38; N. variants: 2
Disease: Severe dehydration ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3472181
Disease: Severe dehydration
Severe dehydration 		0.010 Biomarker disease BEFREE GCC and its endogenous peptide ligands, guanylin and uroguanylin, play a key role in balancing water absorption and hydration of the intestinal lumen, as exemplified by the finding that loss of GCC function causes severe dehydration of the intestinal lumen, culminating in intestinal obstruction. 30782244 2019