|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.
|
30104761 |
2018 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Genetic alterations of the GUCY1A3 gene, which encodes the α1 subunit of the sGC, are associated with coronary artery disease.
|
27342234 |
2016 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention.
|
30768153 |
2019 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
GWASDB |
Large-scale association analysis identifies new risk loci for coronary artery disease.
|
23202125 |
2013 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.
|
29212778 |
2018 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
The GUCY1A3 gene encoding the α<sub>1</sub> subunit of the soluble guanylyl cyclase (sGC) resides at one of these loci and has been strongly associated with blood pressure and CAD risk.
|
29601927 |
2018 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
GWASCAT |
Association analyses based on false discovery rate implicate new loci for coronary artery disease.
|
28714975 |
2017 |
|
Coronary Artery Disease
|
0.450 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.
|
31228190 |
2019 |
|
Hypertensive disease
|
0.430 |
GeneticVariation
|
group |
BEFREE |
α1-A680T variant in GUCY1A3 as a candidate conferring protection from pulmonary hypertension among Kyrgyz highlanders.
|
25373139 |
2014 |
|
Hypertensive disease
|
0.430 |
GeneticVariation
|
group |
GWASCAT |
Genome-wide association study in Chinese identifies novel loci for blood pressure and hypertension.
|
25249183 |
2015 |
|
Hypertensive disease
|
0.430 |
GeneticVariation
|
group |
BEFREE |
Disrupted nitric oxide signaling due to GUCY1A3 mutations increases risk for moyamoya disease, achalasia and hypertension.
|
26777256 |
2016 |
|
Coronary Arteriosclerosis
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Genetic alterations of the GUCY1A3 gene, which encodes the α1 subunit of the sGC, are associated with coronary artery disease.
|
27342234 |
2016 |
|
Coronary Arteriosclerosis
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Association of the coronary artery disease risk gene GUCY1A3 with ischaemic events after coronary intervention.
|
30768153 |
2019 |
|
Coronary Arteriosclerosis
|
0.340 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation at the coronary artery disease risk locus GUCY1A3 modifies cardiovascular disease prevention effects of aspirin.
|
31228190 |
2019 |
|
Esophageal Achalasia
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Mutations in GUCY1A3 have been recently linked to a recessive syndromic form of moyamoya with esophageal achalasia.
|
30001348 |
2018 |
|
Esophageal Achalasia
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Homozygous mutations in GUCY1A3 have been reported as a cause of MMD and achalasia.
|
26777256 |
2016 |
|
Myocardial Infarction
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
We investigated whether homozygotes of the GUCY1A3 rs7692387 risk (G) allele benefited from aspirin in two long-term, randomized placebo-controlled trials of aspirin in primary CVD prevention: the Women's Genome Health Study (WGHS, N = 23 294) and a myocardial infarction (MI, N = 550) and stroke (N = 382) case-control set from the Physician's Health Study (PHS, N = 22 071).
|
31228190 |
2019 |
|
Myocardial Infarction
|
0.120 |
GeneticVariation
|
disease |
GWASCAT |
A comprehensive 1,000 Genomes-based genome-wide association meta-analysis of coronary artery disease.
|
26343387 |
2015 |
|
Moyamoya disease 1
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
Homozygous mutations in GUCY1A3 have been reported as a cause of MMD and achalasia.
|
26777256 |
2016 |
|
Moyamoya disease 1
|
0.120 |
GeneticVariation
|
disease |
BEFREE |
The authors conducted a genetic study of really interesting new gene (RING) finger protein 213 ( RNF213); actin alpha 2 ( ACTA2); BRCA1/BRCA2-containing complex subunit 3 ( BRCC3); and guanylate cyclase 1, soluble, alpha 3 ( GUCY1A3) as well as a clinical phenotype analysis in Chinese MMD patients to determine whether genetic differences are responsible for the different clinical features that appear in MMD in different ethnicities.
|
27128593 |
2017 |
|
Cardiovascular Diseases
|
0.110 |
GeneticVariation
|
group |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Cardiovascular Diseases
|
0.110 |
GeneticVariation
|
group |
BEFREE |
In two randomized placebo-controlled trials in the setting of primary prevention, aspirin reduced the incidence of CVD events in individuals homozygous for the GUCY1A3 risk (G) allele, whereas heterozygote individuals had more events when taking aspirin.
|
31228190 |
2019 |
|
Cerebrovascular accident
|
0.110 |
GeneticVariation
|
group |
BEFREE |
We investigated whether homozygotes of the GUCY1A3 rs7692387 risk (G) allele benefited from aspirin in two long-term, randomized placebo-controlled trials of aspirin in primary CVD prevention: the Women's Genome Health Study (WGHS, N = 23 294) and a myocardial infarction (MI, N = 550) and stroke (N = 382) case-control set from the Physician's Health Study (PHS, N = 22 071).
|
31228190 |
2019 |
|
Alcohol consumption
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.
|
29912962 |
2018 |