DisGeNET - a database of gene-disease associations

GUCY1A1, guanylate cyclase 1 soluble subunit alpha 1, 2982

N. diseases: 44; N. variants: 20

Source: ALL

Results per page

Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _v

DPI _v

pLI

EI _vda

EL _gda

Score _vda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Variant

Gene

Disease

Risk Allele

Score _vda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C1305849
Disease:

Diastolic blood pressure measurement

0.800

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs7692387

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C1956346
Disease:

Coronary Artery Disease

0.800

GeneticVariation

GWASCAT

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.

29212778

2018

dbSNP:

rs7692387

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C1956346
Disease:

Coronary Artery Disease

0.800

GeneticVariation

GWASDB

Large-scale association analysis identifies new risk loci for coronary artery disease.

23202125

2013

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C1305849
Disease:

Diastolic blood pressure measurement

0.800

GeneticVariation

GWASDB

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

21909115

2011

dbSNP:

rs11724647

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0007222
Disease:

Cardiovascular Diseases

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0023508
Disease:

White Blood Cell Count procedure

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs3796592

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C0871470
Disease:

Systolic Pressure

0.700

GeneticVariation

GWASCAT

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals.

30578418

2019

dbSNP:

rs56329057

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C0871470
Disease:

Systolic Pressure

0.700

GeneticVariation

GWASCAT

Leveraging Polygenic Functional Enrichment to Improve GWAS Power.

30595370

2019

dbSNP:

rs11725969

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs11725969

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C0001948
Disease:

Alcohol consumption

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs11725969

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C0428886
Disease:

Mean blood pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs11725969

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C0871470
Disease:

Systolic Pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs11725969

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C1305849
Disease:

Diastolic blood pressure measurement

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs13131930

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C1956346
Disease:

Coronary Artery Disease

0.700

GeneticVariation

GWASCAT

Identification of 64 Novel Genetic Loci Provides an Expanded View on the Genetic Architecture of Coronary Artery Disease.

29212778

2018

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0428886
Disease:

Mean blood pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0871470
Disease:

Systolic Pressure

0.700

GeneticVariation

GWASCAT

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

29455858

2018

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

29455858

2018

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0871470
Disease:

Systolic Pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0001948
Disease:

Alcohol consumption

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries.

29912962

2018

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C1956346
Disease:

Coronary Artery Disease

0.700

GeneticVariation

GWASCAT

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies.

30104761

2018

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.

27841878

2017

dbSNP:

rs13139571

Entrez Id:	2982;107984032
Gene Symbol:	GUCY1A1;LOC107984032

GUCY1A1;LOC107984032

CUI:	C0871470
Disease:

Systolic Pressure

0.700

GeneticVariation

GWASCAT

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation.

27841878

2017

dbSNP:

rs2306556

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C1956346
Disease:

Coronary Artery Disease

0.700

GeneticVariation

GWASCAT

Association analyses based on false discovery rate implicate new loci for coronary artery disease.

28714975

2017

dbSNP:

rs7692387

Entrez Id:	2982
Gene Symbol:	GUCY1A1

GUCY1A1

CUI:	C0428883
Disease:

Diastolic blood pressure

0.700

GeneticVariation

GWASCAT

Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension.

27618447

2016