GUCY2C, guanylate cyclase 2C, 2984

N. diseases: 88; N. variants: 6
Disease: Intestinal Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0021841
Disease: Intestinal Neoplasms
Intestinal Neoplasms 		0.040 Biomarker group BEFREE It has been suggested that GC-C acts as an intestinal tumor suppressor with the potential to prevent the initiation and progression of colorectal cancer. 29210639 2018
CUI: C0021841
Disease: Intestinal Neoplasms
Intestinal Neoplasms 		0.040 Biomarker group BEFREE GUCY2C recently emerged as an intestinal tumor suppressor coordinating AKT1-dependent crypt-villus homeostasis. 22384056 2012
CUI: C0021841
Disease: Intestinal Neoplasms
Intestinal Neoplasms 		0.040 Biomarker group BEFREE Elimination of CDX2 or GCC promotes intestinal tumor initiation and growth in aged mice, mice carrying APC mutations or mice exposed to carcinogens. 20592492 2010
CUI: C0021841
Disease: Intestinal Neoplasms
Intestinal Neoplasms 		0.040 Biomarker group BEFREE The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling. 19737566 2010