GUCY2C, guanylate cyclase 2C, 2984

N. diseases: 88; N. variants: 6
Disease: Irritable bowel syndrome with constipation ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4268639
Disease: Irritable bowel syndrome with constipation
Irritable bowel syndrome with constipation 		0.030 Biomarker disease BEFREE This study suggests that CIC and IBS-C can be treated by oral GUCY2C hormone replacement. 31318728 2019
CUI: C4268639
Disease: Irritable bowel syndrome with constipation
Irritable bowel syndrome with constipation 		0.030 AlteredExpression disease BEFREE Expert opinion: Given this broad spectrum of potential activity for GC-C agonists, it would not be surprising to see that the use of agents such as plecanatide in new areas grow to a level even greater than the use for the present CIC and IBS-C indications. 29376436 2018
CUI: C4268639
Disease: Irritable bowel syndrome with constipation
Irritable bowel syndrome with constipation 		0.030 Biomarker disease BEFREE This process underlies the utility of exogenous GC-C agonists such as linaclotide for the treatment of chronic idiopathic constipation (CIC) and irritable bowel syndrome with constipation (IBS-C). 28448580 2017