ICOS, inducible T cell costimulator, 29851

N. diseases: 193; N. variants: 9
Disease: Asthma ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0004096
Disease: Asthma
Asthma 		0.140 Biomarker disease BEFREE Type 2 innate lymphoid cell suppression by regulatory T cells attenuates airway hyperreactivity and requires inducible T-cell costimulator-inducible T-cell costimulator ligand interaction. 27717665 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.140 Biomarker disease BEFREE Furthermore, the ratio of cluster of differentiation (CD) 4<sup>+</sup>CXCR5<sup>+</sup>/CD4<sup>+</sup> and CD4<sup>+</sup>CXCR5<sup>+</sup>ICOS<sup>+</sup>/CD4<sup>+</sup>CXCR5<sup>+</sup> was significantly increased in the asthma group. 28810548 2017
CUI: C0004096
Disease: Asthma
Asthma 		0.140 Biomarker disease BEFREE Here we showed that a lack of ICOS on murine ILC2s and blocking the ICOS:ICOS-ligand interaction in human ILC2s reduced AHR and lung inflammation. 25769613 2015
CUI: C0004096
Disease: Asthma
Asthma 		0.140 GeneticVariation disease GWASDB Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia. 21150878 2011
CUI: C0004096
Disease: Asthma
Asthma 		0.140 Biomarker disease BEFREE The establishment of ICOS as an important regulator of Th2 development and effector function makes the ICOS locus an attractive candidate for Th2-mediated diseases, such as asthma and allergy. 16081771 2005