|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
MPO/BAY dendritic cells attenuate established anti-MPO autoimmunity and GN in an antigen-specific manner through ICOS-dependent induction of IL-10-expressing regulatory T cells.
|
31444274 |
2019 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Aire can also be expressed in dendritic cells (DCs), and DCs can mediate T follicular helper (T<sub>FH</sub>) cell differentiation and self-reactive B cell activation through inducible costimulator molecule ligand (ICOSL) and interleukin 6 (IL-6), which can cause autoimmune diseases.
|
31023489 |
2019 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Overall, our data not only show a role of B cell ADAM10 in control autoimmunity but also increase our understanding of the regulation of ICOS and ICOSL in the context of autoimmunity.
|
30610163 |
2019 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Altogether, the deviation of autoimmunity from the pancreas to skeletal muscles in the absence of ICOS/ICOSL signaling in NOD mice is strictly dependent on CD4<sup>+</sup> T-cells, leads to myofiber necrosis and regeneration.
|
28424681 |
2017 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
ICOS stimulates T follicular helper cell differentiation in lymphoid tissue, suggesting that it might drive autoimmunity by enhancing autoantibody production.
|
25786178 |
2015 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
GWASDB |
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
|
21383967 |
2011 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphisms (SNPs) in the CD28/CTLA4/ICOS gene region were reported to be associated with several autoimmune diseases including, type-1 diabetes, SLE, autoimmune thyroid diseases and celiac disease.
|
19672595 |
2010 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Our study suggests that extensive T cell dysfunction, decreased memory T cell compartment, and imbalance between effector and regulatory cells in ICOS-deficient patients may underlie their immunodeficiency and/or autoimmunity.
|
19380800 |
2009 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Two compelling candidate autoimmune disease susceptibility genes are those that encode CTLA4 and inducible costimulator (ICOS), immunoregulatory proteins.
|
19333938 |
2009 |
|
Autoimmune Diseases
|
0.200 |
Biomarker
|
group |
BEFREE |
Cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and inducible T-cell co-stimulator (ICOS) genes are important mediators of T-cell activation in autoimmune diseases.
|
19376178 |
2009 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
Chromosomal region 2q33 encodes the immune regulatory genes, CTLA4, ICOS and CD28, which are involved in regulation of T-cell activity and has been studied as a candidate gene locus in autoimmune diseases, including coeliac disease (CD).
|
16237465 |
2006 |
|
Autoimmune Diseases
|
0.200 |
GeneticVariation
|
group |
BEFREE |
The results show that the ICOS gene is polymorphic, but no variation in the coding sequence was detected, implying that the genetic linkage of this gene region to autoimmune diseases may not result from structural variation in the ICOS molecule.
|
11904679 |
2002 |