ICOS, inducible T cell costimulator, 29851

N. diseases: 193; N. variants: 9
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 1 ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3149378
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 1
IMMUNODEFICIENCY, COMMON VARIABLE, 1 		0.400 Biomarker disease GENOMICS_ENGLAND The 2017 IUIS Phenotypic Classification for Primary Immunodeficiencies. 29226301 2018
CUI: C3149378
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 1
IMMUNODEFICIENCY, COMMON VARIABLE, 1 		0.400 GeneticVariation disease CLINVAR Impaired CD4 and CD8 effector function and decreased memory T cell populations in ICOS-deficient patients. 19380800 2009
CUI: C3149378
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 1
IMMUNODEFICIENCY, COMMON VARIABLE, 1 		0.400 Biomarker disease GENOMICS_ENGLAND Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. 12577056 2003
CUI: C3149378
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 1
IMMUNODEFICIENCY, COMMON VARIABLE, 1 		0.400 Biomarker disease GENOMICS_ENGLAND Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. 12577056 2003
CUI: C3149378
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 1
IMMUNODEFICIENCY, COMMON VARIABLE, 1 		0.400 GeneticVariation disease CLINVAR Homozygous loss of ICOS is associated with adult-onset common variable immunodeficiency. 12577056 2003
CUI: C3149378
Disease: IMMUNODEFICIENCY, COMMON VARIABLE, 1
IMMUNODEFICIENCY, COMMON VARIABLE, 1 		0.400 GeneticVariation disease CLINVAR ICOS is critical for CD40-mediated antibody class switching. 11343122 2001