RMC1, regulator of MON1-CCZ1, 29919

N. diseases: 110; N. variants: 6
Disease: Anorexia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003123
Disease: Anorexia
Anorexia 		0.040 Biomarker disease BEFREE Inhibiting MIC-1/GDF15 or its receptor GFRAL are high-value potential targets for treatment of anorexia/cachexia syndrome in patients whose elevated serum levels may justify its use. 30382947 2018
CUI: C0003123
Disease: Anorexia
Anorexia 		0.040 AlteredExpression disease BEFREE Moreover, we analysed MIC-1 levels in this tumour model and their correlation with tumour size and the severity of the anorectic response. 28025863 2017
CUI: C0003123
Disease: Anorexia
Anorexia 		0.040 Biomarker disease BEFREE In particular, MIC-1 may contribute to the proliferation, migration, invasion, metastases, and treatment resistance of cancer cells as well as tumor-induced anorexia and weight loss in the late stages of cancer. 20578239 2010
CUI: C0003123
Disease: Anorexia
Anorexia 		0.040 Biomarker disease BEFREE Thus, MIC-1 is a newly defined central regulator of appetite and a potential target for the treatment of both cancer anorexia and weight loss, as well as of obesity. 17982462 2007