|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Macrophage inhibitory cytokine-1 (MIC-1), a transforming growth factor-β superfamily cytokine, is involved in tumor pathogenesis, and its measurement can be used as a clinical tool for the diagnosis of a wide range of cancers.
|
28834599 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The patients bearing larger tumors, those with distant metastases, and those with later-stage tumors had relatively higher levels of MIC-1.
|
30546400 |
2018 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Moreover, we analysed MIC-1 levels in this tumour model and their correlation with tumour size and the severity of the anorectic response.
|
28025863 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
This has led us to focus on molecules associated with resistance, such as the molecular chaperones heat shock proteins (HSPs) and clusterin (CLU), and the cytokines interleukin-6 (IL-6) and the divergent member of the tumor growth factor family MIC-1 (macrophage inhibitory cytokine-1 also named GDF-15).
|
24969394 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
MIC-1 expression in tumor tissue was analyzed by RT-PCR from 64 patients with PDAC.
|
25106741 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We conclude that EPEC enhances MIC-1 gene expression in the human intestinal cancer cells, which can be associated with enhanced tumor cell resistance to anchorage-dependent tumor cell death via enhanced TAK1 and RhoA GTPase.
|
23503457 |
2013 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Instead, inhibition of MIC-1 was found to mechanistically retard melanoma tumor vascular development, subsequently affecting tumor cell proliferation and apoptosis.
|
20431030 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results indicate that MIC-1 may function to promote development of more aggressive melanoma tumors.
|
18754039 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
When MIC-1 or PLAU action was repressed in the tumor cells, the chemical ribotoxic stress triggered a survival-related MAP kinase such as ERK.
|
19540205 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Both MIC-1 and control tumors induced mixed sclerotic/lytic bone lesions, but MIC-1 increased the osteolytic component of tumors.
|
19152406 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Although generally considered to be part of the cell's antitumorigenic repertoire, MIC-1 secretion, processing, and latent storage suggest a complex, dynamic variability in MIC-1 bioavailability in the tumor microenvironment, potentially modulating tumor progression and invasiveness.
|
16707416 |
2006 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
These results suggest that AKT/PKB through MIC-1 could regulate the ERK1 activity and the MIC-1 expression levels may serve as a surrogate marker for the AKT activation in tumors.
|
15677629 |
2005 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
This study examines the relationship of serum MIC-1 levels and genotypes to clinical and pathologic features of colonic neoplasia.
|
12855642 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We show that several of the other candidate genes encode proteins with high levels of tumor-associated expression by immunohistochemistry on tissue microarrays and further demonstrate significantly elevated levels of another novel candidate protein, macrophage inhibitory cytokine 1, a distant member of the transforming growth factor-beta superfamily, in the serum of patients with metastatic prostate, breast, and colorectal carcinomas.
|
12624183 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
When transplanted into nude mice, HCT116 cells continued to secret human MIC-1 and mouse plasma levels correlated well with tumor volume.
|
14578467 |
2003 |