|
Asthma
|
0.700 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma, Aspirin-Induced
|
0.410 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma, Nasal Polyps, And Aspirin Intolerance
|
0.300 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
Nasal Polyps
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Asthma
|
0.700 |
Biomarker
|
disease |
MGD |
Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma.
|
11786643 |
2002 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Mice with a targeted deletion of the T-bet gene and severe combined immunodeficient mice receiving CD4+ cells from T-bet knockout mice spontaneously demonstrated multiple physiological and inflammatory features characteristic of asthma.
|
11786643 |
2002 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
MGD |
Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.
|
11786644 |
2002 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
BEFREE |
Using statistical analyses for association of TBX21 polymorphisms with these three asthma phenotypes, no significant signals were detected.
|
12938094 |
2003 |
|
Immune System Diseases
|
0.010 |
GeneticVariation
|
group |
BEFREE |
TBX21 variation/haplotype information identified in this study will provide valuable information for future association studies of other immunological diseases.
|
12938094 |
2003 |
|
Dermatitis, Atopic
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Semi-quantitative RT-PCR revealed that in peripheral blood mononuclear cells without any stimulation the levels of mRNA for GATA-3 and SOCS-3 were elevated, the levels of mRNA for Txk were depressed and the levels of mRNA for T-bet and SOCS-5 were comparable in patients with atopic dermatitis as compared with healthy controls.
|
15008986 |
2004 |
|
Eczema
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Semi-quantitative RT-PCR revealed that in peripheral blood mononuclear cells without any stimulation the levels of mRNA for GATA-3 and SOCS-3 were elevated, the levels of mRNA for Txk were depressed and the levels of mRNA for T-bet and SOCS-5 were comparable in patients with atopic dermatitis as compared with healthy controls.
|
15008986 |
2004 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
Our study suggests the first evidence of an association between type 1 diabetes and polymorphisms in the T-bet gene, and that variation in T-bet transcriptional activity may play a role in the development of type 1 diabetes, possibly through the effect on IFN-gamma production in Th1 cells.
|
15241679 |
2004 |
|
Asthma
|
0.700 |
AlteredExpression
|
disease |
BEFREE |
Within the Finnish asthmatic founder population, there was no association between T-bet SNPs and high serum IgE level or asthma.
|
15248849 |
2004 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids.
|
15604153 |
2004 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
TBX21 may thus be an important determinant pharmacogenetic response to the therapy of asthma with inhaled corticosteroids.
|
15604153 |
2004 |
|
Hodgkin Disease
|
0.010 |
Biomarker
|
disease |
LHGDN |
T-bet, a T cell-associated transcription factor, is expressed in Hodgkin's lymphoma.
|
15712176 |
2005 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
CTD_human |
In order to examine whether polymorphisms in the candidate gene, TBX21, located on chromosome 17q21.32, are related to the risk of human asthma phenotypes, we have searched for genetic variations in the human TBX21 gene and identified 24 single nucleotide polymorphisms (SNPs), including five novel SNPs, by direct sequencing in Japanese subjects.
|
15806396 |
2005 |
|
Asthma
|
0.700 |
Biomarker
|
disease |
BEFREE |
Mice lacking the T-bet gene (tbx21) demonstrate multiple physiological and inflammatory features reminiscent of human asthma.
|
15806396 |
2005 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
In order to examine whether polymorphisms in the candidate gene, TBX21, located on chromosome 17q21.32, are related to the risk of human asthma phenotypes, we have searched for genetic variations in the human TBX21 gene and identified 24 single nucleotide polymorphisms (SNPs), including five novel SNPs, by direct sequencing in Japanese subjects.
|
15806396 |
2005 |
|
Asthma, Aspirin-Induced
|
0.410 |
GeneticVariation
|
disease |
BEFREE |
Functional promoter polymorphism in the TBX21 gene associated with aspirin-induced asthma.
|
15806396 |
2005 |
|
Asthma
|
0.700 |
GeneticVariation
|
disease |
LHGDN |
T-bet polymorphisms are associated with asthma and airway hyperresponsiveness.
|
16179640 |
2006 |
|
Uveitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
T-bet protein was detectable in VKH patients during an active uveitis episode, but not in quiescent patients nor in the healthy controls.
|
16234441 |
2005 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
As compared with tumors with signs of early metastatic invasion, tumors without such signs had increased infiltrates of immune cells and increased levels of messenger RNA (mRNA) for products of type 1 helper effector T cells (CD8, T-BET [T-box transcription factor 21], interferon regulatory factor 1, interferon-gamma, granulysin, and granzyme B) but not increased levels of inflammatory mediators or immunosuppressive molecules.
|
16371631 |
2005 |
|
Aplastic Anemia
|
0.030 |
AlteredExpression
|
disease |
LHGDN |
T-bet, a Th1 transcription factor, is up-regulated in T cells from patients with aplastic anemia.
|
16434488 |
2006 |
|
Asthma, Aspirin-Induced
|
0.410 |
Biomarker
|
disease |
CTD_human |
Several single nucleotide polymorphisms (SNPs) in the promoters of EP2, TBX21, COX-2, Fc epsilon RIbeta, and TBXA2R were associated with AIA, while an Fc epsilon RIalpha promoter polymorphism was associated with AIU.
|
16502481 |
2006 |