|
Androgen-Insensitivity Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
ChIP-seq showed that HDAC2 binding sites were enriched in regulation of Th1 cytokine production, and ChIP-PCR confirmed that HDAC2 binding was changed at the intron of STAT4 and the promoter of T-box transcription factor 21 (T-bet) in lymphocytes from AIS patients.
|
31465536 |
2020 |
|
Alzheimer's Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sixty-four patients with probable or possible AD associated with DM were classified using PiB (detects amyloid, A) and PBB3 (detects tau, T) PET studies.
|
31356213 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sixty-four patients with probable or possible AD associated with DM were classified using PiB (detects amyloid, A) and PBB3 (detects tau, T) PET studies.
|
31356213 |
2019 |
|
Angioimmunoblastic Lymphadenopathy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Gene expression profiling (GEP) defined molecular signatures for AITL and delineated biological and prognostic subgroups within PTCL-NOS (PTCL-GATA3 and PTCL-TBX21).
|
30782609 |
2019 |
|
Liver neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
We established a respiratory-gated DWI protocol for a preclinical 1 T PET/MRI scanner allowing to monitor growth-related changes in ADC values of orthotopic HCC liver tumors.
|
30796555 |
2019 |
|
Virus Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
The Transcription Factor T-Bet Is Required for Optimal Type I Follicular Helper T Cell Maintenance During Acute Viral Infection.
|
30984183 |
2019 |
|
Deep caries
|
0.010 |
GeneticVariation
|
phenotype |
BEFREE |
Therefore, this study comprises a case-control and functional investigation of Tbx21 genetic variations impact on Th1 response in vivo and in vitro, and its impact on periapical lesions risk and outcome, performed with a population of healthy controls (H; N = 283) and patients presenting periapical lesions (L; N = 188) or deep caries (DC; N = 152).
|
30548981 |
2019 |
|
Influenza A virus infection
|
0.010 |
Biomarker
|
disease |
BEFREE |
Early T-BET Expression Ensures an Appropriate CD8<sup>+</sup> Lineage-Specific Transcriptional Landscape after Influenza A Virus Infection.
|
31227580 |
2019 |
|
Idiopathic Pulmonary Fibrosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The short telomere defect in IPF-LTRs was associated with significantly impaired CMV-specific proliferative responses, T-cell effector functions, and induction of the major type-1 transcription factor T-bet (T-box 21;TBX21).
|
30088779 |
2019 |
|
Latent autoimmune diabetes mellitus in adult
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The data confirmed that sitagliptin altered the phenotype of T cells and downregulated the expression of T-BET and RORC in LADA patients, and ameliorated glycemic control in LADA patients.
|
29883070 |
2019 |
|
Liver carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We established a respiratory-gated DWI protocol for a preclinical 1 T PET/MRI scanner allowing to monitor growth-related changes in ADC values of orthotopic HCC liver tumors.
|
30796555 |
2019 |
|
Triple Negative Breast Neoplasms
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of the 242 TNBC cases, CD8 was positively expressed in 127 (52.5%) tumors, and T-bet was positively expressed in 67 (27.7%) tumors.
|
31069590 |
2019 |
|
Triple-Negative Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Of the 242 TNBC cases, CD8 was positively expressed in 127 (52.5%) tumors, and T-bet was positively expressed in 67 (27.7%) tumors.
|
31069590 |
2019 |
|
Primary biliary cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In the liver of patients with PBC (n = 7) a significantly higher proportion of IL-12Rβ2<sup>+</sup>Tregs (16% on average) was detected (p < 0.05) compared to other liver disease controls (5%)(n = 18) which also showed ex vivo high IFNG and TBET expression.
|
30119881 |
2018 |
|
Ulcerative Colitis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
Crohn Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Eight functional SNPs were associated with anti-TNF response either among patients with CD (TLR5 (rs5744174) and IFNGR2 (rs8126756)), UC (IL12B (rs3212217), IL18 (rs1946518), IFNGR1 (rs2234711), TBX21 (rs17250932) and JAK2 (rs12343867)) or in the combined cohort of patient with CD and UC (IBD) (NLRP3 (rs10754558), IL12B (rs3212217) and IFNGR1 (rs2234711)) (P<0.05).
|
28139755 |
2018 |
|
Pneumonia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, an increased prevalence of NTM infections is associated with worsening lung function in CF patients who are also coinfected with <i>Aspergillus fumigatus</i> We established a new mouse model to investigate the relationship between <i>A. fumigatus</i> and <i>M. abscessus</i> pulmonary infections.In this model, animals exposed to <i>A. fumigatus</i> and coinfected with <i>M. abscessus</i> exhibited increased lung inflammation and decreased mycobacterial burden compared with those of mice infected with <i>M. abscessus</i> alone.This increased control of <i>M. abscessus</i> infection in coinfected mice was mucus independent but dependent on both transcription factors T-box 21 (Tbx21) and retinoic acid receptor (RAR)-related orphan receptor gamma t (RORγ-t), master regulators of type 1 and type 17 immune responses, respectively.
|
29263106 |
2018 |
|
Adenocarcinoma of lung (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
TBX21 predicts prognosis of patients and drives cancer stem cell maintenance via the TBX21-IL-4 pathway in lung adenocarcinoma.
|
29615105 |
2018 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data demonstrated a key role of TBX21 in the maintenance of cancer stemness and that the TBX21-IL-4 pathway is a crucial factor contributing to lung carcinogenesis.
|
29615105 |
2018 |
|
Tumor Initiation
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Furthermore, the study showed that TBX21 activation transduced a TBX21-IL-4 signaling cascade to promote tumor initiation, tumor growth and expression of stemness markers.
|
29615105 |
2018 |
|
Pneumonitis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, an increased prevalence of NTM infections is associated with worsening lung function in CF patients who are also coinfected with <i>Aspergillus fumigatus</i> We established a new mouse model to investigate the relationship between <i>A. fumigatus</i> and <i>M. abscessus</i> pulmonary infections.In this model, animals exposed to <i>A. fumigatus</i> and coinfected with <i>M. abscessus</i> exhibited increased lung inflammation and decreased mycobacterial burden compared with those of mice infected with <i>M. abscessus</i> alone.This increased control of <i>M. abscessus</i> infection in coinfected mice was mucus independent but dependent on both transcription factors T-box 21 (Tbx21) and retinoic acid receptor (RAR)-related orphan receptor gamma t (RORγ-t), master regulators of type 1 and type 17 immune responses, respectively.
|
29263106 |
2018 |
|
Incontinentia Pigmenti Achromians
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Triggering receptor expressed on myeloid cell-1 (TREM-1) may play a vital role in mammalian target of rapamycin (mTOR) modulation of CD8+ T-cell differentiation through the transcription factors T-box expressed in T-cells and eomesodermin during the immune response to invasive pulmonary aspergillosis (IPA).
|
28485322 |
2017 |
|
Invasive Pulmonary Aspergillosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Triggering receptor expressed on myeloid cell-1 (TREM-1) may play a vital role in mammalian target of rapamycin (mTOR) modulation of CD8+ T-cell differentiation through the transcription factors T-box expressed in T-cells and eomesodermin during the immune response to invasive pulmonary aspergillosis (IPA).
|
28485322 |
2017 |
|
Prostate cancer recurrent
|
0.010 |
Biomarker
|
disease |
BEFREE |
[<sup>68</sup>Ga]PSMA I&T PET/CT has high detection rates of recurrent prostate cancer that are comparable to [<sup>68</sup>Ga]PSMA HBED-CC.
|
27896369 |
2017 |
|
Epithelial ovarian cancer
|
0.010 |
Biomarker
|
disease |
BEFREE |
Higher Numbers of T-Bet+ Tumor-Infiltrating Lymphocytes Associate with Better Survival in Human Epithelial Ovarian Cancer.
|
28214872 |
2017 |