TLX3, T cell leukemia homeobox 3, 30012

N. diseases: 34; N. variants: 0
Disease: Lymphoid leukemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia 		0.020 GeneticVariation disease BEFREE The most common recurrent cytogenetic abnormalities in T-lymphoblastic leukemia (T-acute lymphoblastic leukemia [T-ALL]) involve T-cell receptor (TCR) loci and a variety of partner genes, including HOX11, HOX11L2, MYC, and TAL1. 22563559 2012
CUI: C0023448
Disease: Lymphoid leukemia
Lymphoid leukemia 		0.020 Biomarker disease BEFREE On multivariable analysis high ERG expression (P = .005), immunophenotypic subgroups (early v mature v thymic T-ALL; overall P = .04), HOX11L2 positivity (P = .055), and absence of HOX11 (P = .017) were independent adverse risk factors predicting RFS. 16954520 2006