H2AX, H2A.X variant histone, 3014

N. diseases: 212; N. variants: 6
Disease: Pulmonary Emphysema ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.020 PosttranslationalModification disease BEFREE We also observed low phosphorylation of H2AX, which activates DSBs repair signaling, in emphysema. 30696938 2019
CUI: C0034067
Disease: Pulmonary Emphysema
Pulmonary Emphysema 		0.020 AlteredExpression disease BEFREE The ratio of ionizing radiation-induced γ-H2AX level to the baseline was used to evaluate interindividual variation of DSB damage response and to assess the risk of lung cancer by using unconditional multivariable logistic regression with adjustment of age, sex, ethnicity, smoking status, family history of lung cancer, dust exposure, and emphysema. 23300022 2013