|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
The variants in HAGH, rs11859266 and rs3743852, showed significant associations with schizophrenia in males at allelic and genotype levels, which remained persistent after multiple testing with the exception of rs3743852 for the genotype model.
|
25645869 |
2015 |
|
Schizophrenia
|
0.310 |
GeneticVariation
|
disease |
BEFREE |
The variants in HAGH, rs11859266 and rs3743852, showed significant associations with schizophrenia in males at allelic and genotype levels, which remained persistent after multiple testing with the exception of rs3743852 for the genotype model.
|
25645869 |
2015 |
|
Liver Cirrhosis, Experimental
|
0.300 |
Biomarker
|
disease |
CTD_human |
Systems level analysis and identification of pathways and networks associated with liver fibrosis.
|
25380136 |
2014 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
In prostate cancer (PCa), the role of Glo2 has been scarcely investigated and there are no studies addressing a causative involvement of this protein in this neoplasia.
|
28470764 |
2017 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Glo2 expression in PCa was dependent on androgen receptor (AR) and was aimed at stimulating cell proliferation and eluding apoptosis through a mechanism involving the p53-p21 axis.
|
28470764 |
2017 |
|
Malignant neoplasm of prostate
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Glo2 and Glo1 expression was examined in clinical samples of PCa by immunohistochemistry and in different PCa cell models by western blotting and quantitative real-time polymerase chain reaction.
|
27696457 |
2017 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Glo2 and Glo1 expression was examined in clinical samples of PCa by immunohistochemistry and in different PCa cell models by western blotting and quantitative real-time polymerase chain reaction.
|
27696457 |
2017 |
|
Prostate carcinoma
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Glo2 expression in PCa was dependent on androgen receptor (AR) and was aimed at stimulating cell proliferation and eluding apoptosis through a mechanism involving the p53-p21 axis.
|
28470764 |
2017 |
|
Neoplasms
|
0.020 |
AlteredExpression
|
group |
BEFREE |
In contrast, GII showed a higher activity in the tumour (either SBC or IBC samples) versus normal tissues.
|
12204678 |
2002 |
|
Non-Small Cell Lung Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
In the present study, we evaluated whether and how Glo2 participated in the proapoptotic effects of OP in NSCLC A549 cells.
|
31428230 |
2019 |
|
Rett Syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results revealed that RTT is linked to an alteration of the GLOs system (specifically, increased GLO2 activity), that ensures unchanged MG-dependent damage levels.
|
30781346 |
2019 |
|
Carcinogenesis
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
The causative and mechanistic role of Glo2 in prostate tumorigenesis was demonstrated by Glo2 ectopic expression/silencing and employing specific activators/inhibitors.
|
28470764 |
2017 |
|
Alzheimer's Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
(13)C-NMR spectroscopy revealed a shift in the Glx-2/Glx-4-ratio-where Glx represents a combined Glu/Gln-signal-towards Glx-2 in AD.
|
25742870 |
2015 |
|
Autism Spectrum Disorders
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Our aim was to analyse genetic variants of GLO1 and HAGH in population of 143 paediatric participants with ASD.
|
24671236 |
2015 |
|
Prostatic Neoplasms
|
0.010 |
AlteredExpression
|
group |
LHGDN |
Alteration of glyoxalase genes expression in response to testosterone in LNCaP and PC3 human prostate cancer cells.
|
18344682 |
2007 |
|
Adenocarcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
In addition, glyoxalase II activity decrease in the adenocarcinoma tissue suggests a likely role of the intermediate S-D-lactoylglutathione by supplying energy in actively proliferating cells.
|
16803681 |
2006 |
|
Adenocarcinoma, Clear Cell
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The purpose of this study was to investigate the messenger RNA expression and activity of glyoxalase I and glyoxalase II enzymes in a human renal carcinoma (clear cell adenocarcinoma) and in pair-matched normal tissue.
|
16803681 |
2006 |
|
Carcinoma
|
0.010 |
AlteredExpression
|
group |
BEFREE |
This work aimed to study the activities of the glyoxalase system enzymes (glyoxalase I (GI) and glyoxalase II (GII) and their gene expression in human bladder carcinomas compared with the corresponding normal mucosa.
|
12204678 |
2002 |
|
Inflammatory Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
In contrast, GII showed a higher activity in the tumour (either SBC or IBC samples) versus normal tissues.
|
12204678 |
2002 |
|
Breast Carcinoma
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
The present work aimed to study the activities of glyoxalase system enzymes, glyoxalase I (G I) and glyoxalase II (G II), as well as the expression of their genes in human breast carcinoma.
|
11368412 |
2001 |
|
Polycystic Kidney, Autosomal Dominant
|
0.010 |
Biomarker
|
disease |
BEFREE |
Other genes mapped to this area (16p13.3) include phosphodiesterase IB (PDE1B), hydroxyacyl-glutathione hydrolase (HAGH), phosphoglycolate phosphatase (PGP), and the gene that causes adult polycystic kidney disease (PKD1).
|
1285890 |
1993 |
|
Rheumatoid Arthritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In contrast, in patients with RA abnormal frequencies of the MHC antigens DR4 and DR2 and the extended haplotypes associated with them [B62 BfS C4A3 C4B3 DR4 GLO2] and [B7 BfS C4A3 C4B1 DR2] confirmed the observations reported on other white populations.
|
2111123 |
1990 |
|
Kidney Failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with the extended haplotype B8,DR3,SC01,GLO2 had a higher incidence of renal insufficiency than those without it (P less than 0.01).
|
3458025 |
1986 |
|
Renal Insufficiency
|
0.010 |
Biomarker
|
disease |
BEFREE |
Patients with the extended haplotype B8,DR3,SC01,GLO2 had a higher incidence of renal insufficiency than those without it (P less than 0.01).
|
3458025 |
1986 |